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CYP3A4 metabolite of midazolam.
Bottomless glass bottle. Contents are inside inserted fused cone.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. UC430.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Determination of midazolam and its major metabolite 1'-hydroxymidazolam by high-performance liquid chromatography-electrospray mass spectrometry in plasma from children. Muchohi SN, Ward SA, Preston L, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 821(1), 1-7, (2005)
Development and validation of a method using supported liquid extraction for the simultaneous determination of midazolam and 1'-hydroxy-midazolam in human plasma by liquid chromatography with tandem mass spectrometry detection. Svanström C, Hansson GP, Svensson LD, et al. J. Pharm. Biomed. Anal. 58, 71-7, (2012)
Determination of midazolam and 1-hydroxymidazolam from plasma by gas chromatography coupled to methane negative chemical ionization mass spectrometry after sublingual administration of midazolam. Kaartama R, Jarho P, Savolainen J, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(19), 1668-76, (2011)
Rapid and simultaneous measurement of midazolam, 1'-hydroxymidazolam and digoxin by liquid chromatography/tandem mass spectrometry: application to an in vivo study to simultaneously measure P-glycoprotein and cytochrome P450 3A activity. Xue X, Huang M, Xiao H, et al. J. Pharm. Biomed. Anal. 55(1), 187-93, (2011)
Application of dried blood spot sampling combined with LC-MS/MS for genotyping and phenotyping of CYP450 enzymes in healthy volunteers. de Boer T, Wieling J, Meulman E, et al. Biomed. Chromatogr. 25(10), 1112-23, (2011)
A highly sensitive liquid chromatography tandem mass spectrometry method for simultaneous quantification of midazolam, 1'-hydroxymidazolam and 4-hydroxymidazolam in human plasma. de Loor H, de Jonge H, Verbeke K, et al. Biomed. Chromatogr. 25(10), 1091-8, (2011)
Metabolism of 1'- and 4-hydroxymidazolam by glucuronide conjugation is largely mediated by UDP-glucuronosyltransferases 1A4, 2B4, and 2B7. Seo KA, Bae SK, Choi YK, et al. Drug Metab. Dispos. 38(11), 2007-13, (2010)
Population pharmacokinetics of midazolam and its metabolites during venoarterial extracorporeal membrane oxygenation in neonates. Ahsman MJ, Hanekamp M, Wildschut ED, et al. Clin. Pharmacokinet. 49(6), 407-19, (2010)
Development and validation of a rapid and sensitive assay for simultaneous quantification of midazolam, 1'-hydroxymidazolam, and 4-hydroxymidazolam by liquid chromatography coupled to tandem mass-spectrometry. Dostalek M, Macwan JS, Chitnis SD, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 878(19), 1629-33, (2010)
High-throughput analysis of in vitro cytochrome p450 inhibition samples using mass spectrometry coupled with an integrated liquid chromatography/autosampler system. Brown A, Bickford S, Hatsis P, et al. Rapid Commun. Mass Spectrom. 24(8), 1207-10, (2010)
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