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UC430 Sigma

1′-Hydroxymidazolam

Synonym: 8-Chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5a][1,4]benzodiazepine

  • CAS Number 59468-90-5

  • Empirical Formula (Hill Notation) C18H13ClFN3O

  • Molecular Weight 341.77

  •  MDL number MFCD00871458

  •  PubChem Substance ID 24724655

Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Drug and Xenobiotic Metabolism,
drug control   regulated under CDSA - not available from Sigma-Aldrich Canada
color   white to off-white
storage temp.   2-8°C

Description

Application

CYP3A4 metabolite of midazolam.

1′-Hydroxymidazolam (1′-OHMDZ) can be used for assessing Cyp3a11 enzyme activity as well as for pharmacokinetic (PK) study of midazolam.1

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Biochem/physiol Actions

1′-Hydroxymidazolam is the major hydroxylated metabolite of Midazolam (MDZ), forms due to rapid and extensive metabolization of MDZ by the CYP 450 3A isoenzymes in the liver. The product contributes to the pharmacological impact of MDZ.2

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. UC430.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

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