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CYP3A4 metabolite of midazolam.
Bottomless glass bottle. Contents are inside inserted fused cone.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. UC431.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Determination of midazolam and its major metabolite 1'-hydroxymidazolam by high-performance liquid chromatography-electrospray mass spectrometry in plasma from children. Muchohi SN, Ward SA, Preston L, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 821(1), 1-7, (2005)
Simultaneous determination of midazolam and its metabolites 1-hydroxymidazolam and 4-hydroxymidazolam in human serum using gas chromatography-mass spectrometry. Martens J and Banditt P J. Chromatogr. B. Biomed. Sci. Appl. 692(1), 95-100, (1997)
Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human, and cdna-expressed human cytochrome P450. Ghosal A, Satoh H, Thomas PE, et al. Drug Metab. Dispos. 24(9), 940-7, (1996)
Determination of midazolam and two of its metabolites in human plasma by high-performance liquid chromatography. Mastey V, Panneton AC, Donati F, et al. J. Chromatogr. B, Biomed. Appl. 655(2), 305-10, (1994)
A highly sensitive liquid chromatography tandem mass spectrometry method for simultaneous quantification of midazolam, 1'-hydroxymidazolam and 4-hydroxymidazolam in human plasma. de Loor H, de Jonge H, Verbeke K, et al. Biomed. Chromatogr. 25(10), 1091-8, (2011)
Metabolism of 1'- and 4-hydroxymidazolam by glucuronide conjugation is largely mediated by UDP-glucuronosyltransferases 1A4, 2B4, and 2B7. Seo KA, Bae SK, Choi YK, et al. Drug Metab. Dispos. 38(11), 2007-13, (2010)
Development and validation of a rapid and sensitive assay for simultaneous quantification of midazolam, 1'-hydroxymidazolam, and 4-hydroxymidazolam by liquid chromatography coupled to tandem mass-spectrometry. Dostalek M, Macwan JS, Chitnis SD, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 878(19), 1629-33, (2010)
The CYP3A4*18 allele, the most frequent coding variant in asian populations, does not significantly affect the midazolam disposition in heterozygous individuals. Lee SJ, Lee SS, Jeong HE, et al. Drug Metab. Dispos. 35(11), 2095-101, (2007)
Determination of midazolam and its hydroxy metabolites in human plasma and oral fluid by liquid chromatography/electrospray ionization ion trap tandem mass spectrometry. Link B, Haschke M, Wenk M, et al. Rapid Commun. Mass Spectrom. 21(9), 1531-40, (2007)
Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study. Cameron MD, Wen B, Allen KE, et al. Biochemistry 44(43), 14143-51, (2005)
Determination of picogram levels of midazolam, and 1- and 4-hydroxymidazolam in human plasma by gas chromatography-negative chemical ionization-mass spectrometry. Eap CB, Bouchoux G, Powell Golay K, et al. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 802(2), 339-45, (2004)
Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam. Granvil CP, Yu AM, Elizondo G, et al. Drug Metab. Dispos. 31(5), 548-58, (2003)
Ultrafast liquid chromatography/tandem mass spectrometry bioanalysis of polar analytes using packed silica columns. Shou WZ, Chen YL, Eerkes A, et al. Rapid Commun. Mass Spectrom. 16(17), 1613-21, (2002)
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