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V116 Sigma

Z-VAD-FMK

solid

Synonym: N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone

  • Empirical Formula (Hill Notation) C22H30FN3O7

  • Molecular Weight 467.49

  •  MDL number MFCD01074990

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Description

Biochem/physiol Actions

Non-selective, cell permeable inhibitor of caspase-1- and caspase-3-related proteases.

Caution

Hygroscopic

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Price and Availability

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DISCOVER Bioactive Small Molecules

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Safety & Documentation

Safety Information

WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Clinical, Diseases, Ligands, Neurodegenerative Diseases

Peer-Reviewed Papers

References

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Netrin-1 is a survival factor during commissural neuron navigation. Furne C, Rama N, Corset V, Chedotal A, Mehlen P Proc. Natl. Acad. Sci. U. S. A., 14465-70, (2008)

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Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance. Ho JD, Yeh R, Sandstrom A, Chorny I, Harries WE, Robbins RA, Miercke LJ, Stroud RM Proc. Natl. Acad. Sci. U. S. A., 7437-42, (2009)

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Inhibition of interleukin1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Hara, et al. Proc. Natl. Acad. Sci. U. S. A. 94, 2007-2012, (1997)

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Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak. McCarthy, et al. J. Cell Biol. 136, 215, (1997)

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Multifunctional role of Erk5 in multiple myeloma. Carvajal-Vergara X, et. al. Blood, 4492-9, (2006)

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Selective activation of caspases during apoptotic induction in HL-60 cells. Effects of a tetrapeptide inhibitor. Polverino, A.J., Patterson, S.D. J. Biol. Chem. 272, 7013, (1997)

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Apoptosis in cerebellar granule neurones: involvement of interleukin-1β converting enzyme-like proteases. Taylor, et al. J. Neurochem. 68, 1598, (1997)

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Human macrophages infected with a high burden of ESAT-6-expressing M. tuberculosis undergo caspase-1- and cathepsin B-independent necrosis. Welin A, Eklund D, Stendahl O, et al. PLoS ONE 6(5), e20302, (2011)

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ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid. Zhang H, Lei Y, Yuan P, et al. PLoS ONE 9(5), e96418, (2014)

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Kaposi's sarcoma-associated herpesvirus confers a survival advantage to endothelial cells. Wang L Cancer Res. 68(12), 4640-8, (2008)

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Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathway. Mercedes Lioni et al Mol. Cancer Ther. 7, 2866-75, (2010)

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Apoptosis in transgenic mice expressing the P301L mutated form of human tau. Ramalho RM Mol. Med. 14(5-6), 309-17, (2008)

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Firefly luciferase and RLuc8 exhibit differential sensitivity to oxidative stress in apoptotic cells. Czupryna J and Tsourkas A PLoS ONE 6(5), e20073, (2011)

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