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V116 Sigma

Z-VAD-FMK

solid

Synonym: N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone

  • Empirical Formula (Hill Notation) C22H30FN3O7

  • Molecular Weight 467.49

  •  MDL number MFCD01074990

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Description

Biochem/physiol Actions

Non-selective, cell permeable inhibitor of caspase-1- and caspase-3-related proteases.

Caution

Hygroscopic

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Price and Availability

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Safety & Documentation

Safety Information

WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Apoptosis in cerebellar granule neurones: involvement of interleukin-1β converting enzyme-like proteases. Taylor, et al. J. Neurochem. 68, 1598, (1997)

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Kaposi's sarcoma-associated herpesvirus confers a survival advantage to endothelial cells. Wang L Cancer Res. 68(12), 4640-8, (2008)

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ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid. Zhang H, Lei Y, Yuan P, et al. PLoS ONE 9(5), e96418, (2014)

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Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathway. Mercedes Lioni et al Mol. Cancer Ther. 7, 2866-75, (2010)

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Apoptosis in transgenic mice expressing the P301L mutated form of human tau. Ramalho RM Mol. Med. 14(5-6), 309-17, (2008)

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Inhibition of interleukin1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Hara, et al. Proc. Natl. Acad. Sci. U. S. A. 94, 2007-2012, (1997)

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Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bcl-2 homologue Bak. McCarthy, et al. J. Cell Biol. 136, 215, (1997)

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Selective activation of caspases during apoptotic induction in HL-60 cells. Effects of a tetrapeptide inhibitor. Polverino, A.J., Patterson, S.D. J. Biol. Chem. 272, 7013, (1997)

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Human macrophages infected with a high burden of ESAT-6-expressing M. tuberculosis undergo caspase-1- and cathepsin B-independent necrosis. Welin A, Eklund D, Stendahl O, et al. PLoS ONE 6(5), e20302, (2011)

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Multifunctional role of Erk5 in multiple myeloma. Carvajal-Vergara X, et. al. Blood, 4492-9, (2006)

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Netrin-1 is a survival factor during commissural neuron navigation. Furne C, Rama N, Corset V, Chedotal A, Mehlen P Proc. Natl. Acad. Sci. U. S. A., 14465-70, (2008)

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Firefly luciferase and RLuc8 exhibit differential sensitivity to oxidative stress in apoptotic cells. Czupryna J and Tsourkas A PLoS ONE 6(5), e20073, (2011)

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Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance. Ho JD, Yeh R, Sandstrom A, Chorny I, Harries WE, Robbins RA, Miercke LJ, Stroud RM Proc. Natl. Acad. Sci. U. S. A., 7437-42, (2009)

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