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V1260 Sigma

VEGF Receptor-3 (Flt-4)/Fc Chimera human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym: Vascular Endothelial Growth Factor Receptor‑3

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Description

Analysis Note

The binding affinity of recombinant VEGF R3 has not been determined. Its intended use is for western blot and ELISA standards.

Physical form

Lyophilized from a 2 μm filtered solution in phosphate buffered saline.

Application

VEGF Receptor-3 (Flt-4)/Fc chimera human is a disulfide-linked homodimeric protein that consists of VEGF Receptor-3 fused with6X histidine tagged Fc portion of human IgG1 by a polypeptide linker. It may be used as a specific marker for lymphatic vessels as well as plays a pivotal role in the development of the lymphatic vessel system.

Biochem/physiol Actions

VEGF Receptor-3 (Flt-4) belongs to class III subfamily of RTKs and is expressed mainly in endothelial cells. VEGF Receptor-3 blocks VEGF-C/D and hence inhibits lymphangiogenesis and lymphatic metastasis in orthotopic urinary bladder cancer (OUBC).

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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