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V1377 Sigma

Vinblastine sulfate salt

powder, ≥96% (HPLC)

Synonym: VLB, Vincaleukoblastine sulfate salt

  • CAS Number 143-67-9

  • Empirical Formula (Hill Notation) C46H58N4O9 · H2SO4

  • Molecular Weight 909.05

  •  Beilstein Registry Number 3659812

  •  EC Number 205-606-0

  •  MDL number MFCD00082457

  •  PubChem Substance ID 24278771

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application,
InChI Key   KDQAABAKXDWYSZ-PNYVAJAMSA-N
assay   ≥96% (HPLC)
form   powder
color   white
mp   267 °C (dec.)(lit.)
solubility   H2O: soluble10 mg/mL
  DMSO: soluble50 mg/mL
absorption   A1mM/214 nm, ethanol 53.7
  A1mM/259 nm, ethanol 16.2
  A1mM/270 nm, 0.1 M phosphate buffer 14
originator   Eli Lilly
storage temp.   2-8°C
Gene Information   human ... TBCC(6903)

Description

Biochem/physiol Actions

Plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing self-association in spiral aggregates in a reaction that appears to be regulated by the C-terminus of β-tubulin and is enhanced by GDP and GTP. Depolymerizes microtubules. Arrests the cell cycle in G2/M-phase by blocking mitotic spindle formation. Triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. Substrate of Pgp and CYP3A4.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

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Price and Availability

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

ABC Transporters and Cancer Drug Resistance

Chemotherapy is the treatment of choice against many types of cancer. However, over time chemotherapeutic drugs can become less effective due to the development of resistance that involves a group of...
BioFiles 2007, 2.4, 7.
Keywords: Absorption, Cancer, Clinical, Cloning, Combinatorial synthesis, Diseases, Enzymology, Gene expression, Genetic, Immunology, Pharmaceutical, Reductions, Search, Transfection, Vectors

Discover Bioactive Small Molecules for ADME/Tox

A significant number of drugs that fail in clinical trials have been associated with safety issues, including unexpected drug-drug interactions (DDI) or lack of efficacy due to poor pharmacokinetics....
Keywords: Absorption, Bioactive small molecules, Clinical, Metabolism

Peer-Reviewed Papers
15

References

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