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V1890 Sigma

Anti-VRK1 (C-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym: Anti-Vaccinia related kinase 1, Anti-Vaccinia virus B1R-related kinase 1

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Primary Antibodies,
species reactivity   human
application(s)   western blot: 1.0-2.0 μg/mL using MCF7 cell lysate
clone   polyclonal
concentration   ~1.0 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt ~45 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... VRK1(7443)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 378-396 of human VRK1, conjugated to KLH. The corresponding sequence is not conserved in mouse and rat VRK1.

General description

VRK1 is serine/threonine kinase that regulates nuclear condensation, mRNA synthesis and cell cycle. This kinase also functions as an upstream regulator of p53 and phosphorylates p53 in Thr18. Phosphorylation of VRK1 in Ser342 by Plk3 induces the fragmentation of Golgi apparatus . Anti-VRK1 (C-terminal) is specific for human VRK1. In immunoblotting, detection of the VRK1 band is specifically inhibited by the VRK1 immunizing peptide.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Application

Anti-VRK1 (C-terminal) is suitable for use in western blot (1.0-2.0 μg/mL) using MCF7 cell lysates.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
RIDADR  NONH for all modes of transport
Protocols & Articles

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Antibody Explorer | Buy Primary & Secondary Antibodies

Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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V1765 Anti-VRK1 antibody produced in rabbit, ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

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