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  • V2132 - [Lys1, Pro2,5, Arg3,4, Tyr6]-Vasoactive Intestinal Peptide human, porcine, rat

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V2132 Sigma

[Lys1, Pro2,5, Arg3,4, Tyr6]-Vasoactive Intestinal Peptide human, porcine, rat

≥97% (HPLC)

Synonym: VIP Antagonist, VIPi, [Lys1, Pro2,5, Arg3,4, Tyr6]-VIP

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Gastrointestinal Peptides, Peptides and Proteins, Peptides for Cell Biology,
InChI Key   FBYWUGLFWCEKAN-KQQCXCAZSA-N
assay   ≥97% (HPLC)
composition   Peptide content, ~70%
storage temp.   −20°C
Gene Information   human ... VIP(7432)

Description

Amino Acid Sequence

Lys-Pro-Arg-Arg-Pro-Tyr-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2

Application

[Lys1, Pro2,5, Arg3,4, Tyr6]-Vasoactive Intestinal Peptide human, porcine, rat wasused as a test compound to study the production of cyclic AMP (cAMP) by different polypeptides in cerebral cortical slices of the chick.

Biochem/physiol Actions

VIP receptor antagonist. Blocks VIP neurotransmission in the exocrine pancreas, but does not block the effects of PACAP, which shares 68% homology with VIP. In contrast, it blocks both VIP- and PACAP-stimulated cyclic AMP accumulation in an osteoblast-like cell line.

[Lys1, Pro2,5, Arg3,4, Tyr6]-Vasoactive Intestinal Peptide human, porcine, rat is a neuropeptide synthesized in the central nervous system that enhances the formation of adenosine 3′,5′-cyclic monophosphate in cerebral cortex and hypothalamus of chick and rat. VIP also modulates the cholinergic as well as serotonergic neurotransmitter systems.

Price and Availability


Amplified Detection

All labs need water

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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