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  • V2138 - [Phenylacetyl1, O-Me-D-Tyr2, Arg6,8, Lys9]-Vasopressin amide

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V2138 Sigma

[Phenylacetyl1, O-Me-D-Tyr2, Arg6,8, Lys9]-Vasopressin amide

>98% (HPLC), solid

  • Empirical Formula (Hill Notation) C59H86N18O12

  • Molecular Weight 1239.43

  •  MDL number MFCD00237315

  •  PubChem Substance ID 329829032

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Oxytocin & Vasopressin,
InChI Key   ARYIFIDWSDPRCG-LABPQDBOSA-N
assay   >98% (HPLC)
form   solid
solubility   H2O: soluble1 mg/mL
storage temp.   −20°C
Gene Information   human ... AVPR1A(552)
mouse ... AVPR1A(54140)
rat ... AVPR1A(25107)

Description

Amino Acid Sequence

Phenylac-MeTyr-Phe-Gln-Asn-Arg-Pro-Arg-Lys-NH2

Biochem/physiol Actions

Selective antagonist having an extremely high affinity for the V-1a vasopressin receptors.

Phenylacetyl1, O-Me-D-Tyr2, Arg6,8, Lys9]-Vasopressin amide is a selective antagonist with high affinity for the V-1a vasopressin receptors. Vasopressin can stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock.It can also stimulate three acid-base transporters and hence increases the capability of the cell to regulate pHi. Additionally, it can induce reversible translocation of aquaporin-CD water channels from intracellular vesicles to apical plasma membrane, which in turn increases the water permeability of collecting duct cells.

Preparation Note

Phenylacetyl1, O-Me-D-Tyr2, Arg6,8, Lys9]-Vasopressin amide dissolves in water at 1 mg/ml.

Application

Phenylacetyl1, O-Me-D-Tyr2, Arg6,8, Lys9]-Vasopressin amide was used as a test compound to study the effects of hypophysectomy (HYPOX) or neurointermediate pituitary lobectomy (NIL) on reduce humoral immune responses of rats.

Price and Availability


Amplified Detection

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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