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V2753 Sigma

Virginiamycin M1

~95%

Synonym: Mikamycin A, Staphylomycin

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Biochemicals and Reagents,
biological source   from Streptomyces virginiae
InChI Key   DAIKHDNSXMZDCU-QHKJSJJMSA-N
assay   ~95%
form   powder
color   yellow
solubility   chloroform/methanol: soluble10 mg/mL
Mode of action   protein synthesis | interferes
antibiotic activity spectrum   Gram-positive bacteria
storage temp.   2-8°C

Description

Packaging

5, 10 mg in serum bottle

Application

The antibiotic virginiamycin is produced by Streptomyces virginiae and is a member of the virginiamycin family. Each member is produced as a mixture of two structurally different compounds that exhibit synergistic antibacterial activity. There are two groups: virginiamycin M1 (VM1) and virginiamycin S (VS). VM1 is a polyunsaturated macrocyclic petolide. VM1 and VS are both used to inhibit protein synthesis since they are bacteriostatic. When used in combination they are more effective. Virginiamycin is used as a performance promoter in animal husbandry. They are chemically modified to make therapeutic drugs such as quinupristin and dalfopristin.

Biochem/physiol Actions

Virginiamycin M1 inhibits bacterial protein synthesis at the level of aminoacyl-tRNA binding and peptide bond formation. It inactivates the 50S ribosome. S. virginiae inactivates VM1 by reducing its 16-carbonyl group, forming 16R-dihydroVM1. VM1 reductase participates solely in VM1 inactivation in vivo.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

HPLC Analysis of Peptide Antibiotics on Discovery® C8

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Peptide Antibiotics on Discovery® C8
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

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From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Vitamins, Fat Soluble (A and E) on Discovery® C18
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Peer-Reviewed Papers
15

References

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