|Related Categories||Berberis sp., Biochemicals and Reagents, Cell Biology, Cofactor, Hordeum vulgare (Barley),|
|density||0.984 g/mL at 25 °C(lit.)|
1, 5, 10 g in glass bottle
Vitamin K1 (Phylloquinone) is a lipid soluble polycyclic aromatic ketone used as a cofactor in the formation of coagulation factors II (prothrombin), VII, IX and X; anticoagulant factors protein C and S and as a cell signaling factor.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. V3501.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
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Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediatesvitamin K-dependent intracellular antioxidant function. Westhofen P, Watzka M, et al. J. Biol. Chem. 286, 15085-15094, (2011)
Effects of long-term vitamin K(1) (phylloquinone) or vitamin K(2) (menaquinone-4) supplementation on body composition and serum parameters in rats. Sogabe N, Maruyama R, et al. Bone 48, 1036-1042, (2011)
c-Met-Akt pathway-mediated enhancement of inhibitory c-Raf phosphorylation is involved in vitamin K1 and sorafenib synergy on HCC growth inhibition. Carr BI, Wang Z, Wang M, et al. Cancer Biol. Ther. 12, 531-538, (2011)
Association between circulating vitamin K1 and coronary calcium progression in community-dwelling adults: the Multi-Ethnic Study of Atherosclerosis. Shea MK, Booth SL, Miller ME, et al. Am. J. Clin. Nutr. 98(1), 197-208, (2013)
Modifications ofAOAC Official Method 999.15 to improve the quantitation of vitamin K1 in complex formulated nutritional products. Delmonte P, Barrientos S, and Rader JI J. AOAC Int. 96(1), 91-101, (2013)
A double-blind, placebo-controlled study of the safety and efficacy of vitamin K1 ointment for the treatment of patients with cetuximab-induced acneiform eruption. Hashimoto H, Iwasa S, Yanai T, et al. Jpn. J. Clin. Oncol. 43(1), 92-4, (2013)
Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. Ibarrola-Jurado N, Salas-Salvadó J, Martínez-González MA, et al. Am. J. Clin. Nutr. 96(5), 1113-8, (2012)
Phylloquinone and vitamin D status: associations with incident chronic kidney disease in the Framingham Offspring cohort. O'Seaghdha CM, Hwang SJ, Holden R, et al. Am. J. Nephrol. 36(1), 68-77, (2012)
Analysis of lipids with desorption atmospheric pressure photoionization-mass spectrometry (DAPPI-MS) and desorption electrospray ionization-mass spectrometry (DESI-MS). Suni NM, Aalto H, Kauppila TJ, et al. J. Mass Spectrom. 47(5), 611-9, (2012)
Vitamin K1 enhances sorafenib-induced growth inhibition and apoptosis of human malignant glioma cells by blocking the Raf/MEK/ERK pathway. Du W, Zhou JR, Wang DL, et al. World J. Surg. Oncol. 10, 60, (2012)
The hydrogen-bonded dianion of vitamin K1 produced in aqueous-organic solutions exists in equilibrium with its hydrogen-bonded semiquinone anion radical. Lim ZH, Chng EL, Hui Y, et al. J. Phys. Chem. B 117(8), 2396-402, (2013)
Prevention of vitamin K deficiency bleeding with three oral mixed micellar phylloquinone doses: results of a 6-year (2005-2011) surveillance in Switzerland. Laubscher B, Bänziger O, and Schubiger G Eur. J. Pediatr. 172(3), 357-60, (2013)
Vitamin K deficiency bleeding after NICE guidance and withdrawal of Konakion Neonatal: British Paediatric Surveillance Unit study, 2006-2008. Busfield A, Samuel R, McNinch A, et al. Arch. Dis. Child. 98(1), 41-7, (2013)
Vitamins K interact with N-terminus α-synuclein and modulate the protein fibrillization in vitro. Exploring the interaction between quinones and α-synuclein. da Silva FL, Coelho Cerqueira E, de Freitas MS, et al. Neurochem. Int. 62(1), 103-12, (2013)
A single measurement of serum phylloquinone is an adequate indicator of long-term phylloquinone exposure in healthy older adults. Presse N, Gaudreau P, Greenwood CE, et al. J. Nutr. 142(10), 1910-6, (2012)
VKORC1-dependent pharmacokinetics of intravenous and oral phylloquinone (vitamin K1) mixed micelles formulation. Marinova M, Lütjohann D, Breuer O, et al. Eur. J. Clin. Pharmacol. 69(3), 467-75, (2013)
Chronic Δ⁹-tetrahydrocannabinol exposure induces a sensitization of dopamine D₂/₃ receptors in the mesoaccumbens and nigrostriatal systems. Ginovart N, Tournier BB, Moulin-Sallanon M, et al. Biol. Psychiatry 37(11), 2355-67, (2012)
Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: insights into the biological role of the side chain part of vitamin K. Yoshitomo Suhara et al J. Med. Chem. 54, 4918-22, (2011)
Corp MSDS 1 (2), 3609:C / FT-IR 2 (2), 2485:A / RegBook 1 (2), 1683:J / Sax 6, 1933 / Sigma FT-IR 1 (2), 973:B / Structure Index 1, 267:C:1
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