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V4512 Sigma

Vascular Endothelial Growth Factor from mouse

VEGF, recombinant, expressed in E. coli, powder, suitable for cell culture

Synonym: VEGF, mVEGF



Analysis Note

The biological activity is measured by the ability to stimulate 3H-thymidine incorporation in human umbilical vein endothelial cells (HUVEC) and bovine aortic endothelial cells.

Other Notes

Homodimeric protein consisting of two 165 amino acid polypeptide chains of mouse VEGF.

Physical form

Lyophilized from a 0.2 μm filtered buffered solution.


Vascular endothelial growth factor (VEGF) supports development of new blood vessels during embryonic development and after vascular injury.Vascular endothelial growth factor from mouse was used for ELISA and in matrigel plugs (matrigel was supplemented with VEGF).

General description

Vascular endothelial growth factor is also known as VPF, VEGF and MVCD1. It is secreted from endothelial cells and pericytes in response to hypoxia. It helps in inducing angiogenesis and microvascular hyperpermeability. VEGF levels are associated with vasculitic neuropathy and may be used to predict this disease. It may also act as a marker in the development and progression of early precancerous lesions of oesophagus.

Price and Availability

All labs need water
Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis

Certificate of Origin

Protocols & Articles


VEGF Pathway

Background VEGF Pathway    Ligands    Receptors VEGF – Signal Transduction Factors Regulating VEGF and VEGFR Expression VEGFR in Human Diseases    Cancer    Preeclampsia    Age-related Macular Degene...
Keywords: AGE, Angiogenesis, Apoptosis, Cancer, Cell proliferation, Clinical, Diseases, Gene expression, Growth factors, Infrared spectroscopy, Ligands, Neurodegenerative Diseases, Phosphorylations, Transcription, Transduction

Vascular Endothelial Growth Factors (VEGF)

Vascular endothelial growth factor (VEGF) is a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. Originally known simpl...
Jennifer Fries
BioFiles 2009, 4.5, 26.
Keywords: Angiogenesis, Gene expression, Growth factors, Inflammation, Ligands

Peer-Reviewed Papers


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