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V4758 Sigma

Monoclonal Anti-Vascular Endothelial Growth Factor antibody produced in mouse

clone 26503, purified immunoglobulin, lyophilized powder

Synonym: Anti-VEGF

Properties

Related Categories Alphabetical Index, Angiogenesis, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology,
species reactivity   human, primate
application(s)   capture ELISA: 2-8 μg/mL
  immunohistochemistry: 8-25 μg/mL
  neutralization: suitable
  western blot: 1-2 μg/mL
clone   26503, monoclonal
antibody form   purified immunoglobulin
form   lyophilized powder
isotype   IgG2b
storage temp.   −20°C
Gene Information   human ... VEGFA(7422), VEGFB(7423), VEGFC(7424)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

purified recombinant Sf21-derived human VEGF (165 aa isoform).

General description

The antibody will neutralize the biological activity of recombinant human VEGF165. It also recognizes VEGF121.

Physical form

Lyophilized from a 0.2 μm solution in phosphate buffered saline containing carbohydrates.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
• Western Blotting (1 paper)

Monoclonal Anti-Vascular Endothelial Growth Factor antibody produced in mouse was used to block the interaction between VEGF and kinase domain receptor in Calf Pulmonary Aortic Endothelial (CPAE) cells.

Biochem/physiol Actions

The vascular endothelial growth factor family consists of five members, VEGF-A to VEGF-E. They play important roles in important role in embryonic vasculogenesis, angiogenesis and homeostasis. The interaction between VEGFs and their respective receptors results in the activation of MAPK, PI3K, PKC, FAK and Src kinase pathways.

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