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V4762 Sigma

Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-1 antibody produced in mouse

clone FLT-19, tissue culture supernatant

Synonym: Anti-Flt1 Receptor, Anti-VEGF R-1

Properties

Related Categories Alphabetical Index, Angiogenesis, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology,
species reactivity   human
application(s)   immunohistochemistry (frozen sections): 1:100 using human placenta
  immunoprecipitation: suitable
  indirect ELISA: suitable
  microarray: suitable
clone   FLT-19, monoclonal
antibody form   tissue culture supernatant
isotype   IgG1
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... FLT1(2321)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

recombinant human extracellular domain of VEGFR-1.

General description

Mouse monoclonal clone FLT-19 anti-Vascular Endothelial Growth Factor Receptor-1 antibody recognizes an epitope within amino acid residues 1-251 of the extracellular domain of human VEGF Receptor-1 molecule (Flt1 Receptor). This clone has also been termed 190.11. The antibody does not recognize VEGF Receptor-2 (KDR), VEGF receptor-3 (sFlt4,) and PDGF-Rβ.

The mitogenic activity of VEGF appears to be stimulated by specific VEGF receptors (160-200 kDa) which can be found on the surface of various endothelial cells. VEGF binds to two structurally similar receptor tyrosine kinases; Flt1 (fms-like tyrosine kinase 1, also known as VEGF Receptor-1 (VEGF-R1), and KDR (kinase insert domain containing receptor, also known as VEGF-R2). Studies using KDR and Flt1 stably transfected endothelial cell lines have shown that these two receptors exhibit different affinities to VEGF and mediate different responses. KDR/Flk1 does not respond to placental growth factor (PlGF), a VEGF related growth factor, while Flt1 binds PlGF specifically. Flt1 is predominately expressed in human placenta and human vascular endothelial cells. Both VEGF receptors (KDR and Flt1) are upregulated in human fetal and adult kidney.

Application

Mouse monoclonal clone FLT-19 anti-Vascular Endothelial Growth Factor Receptor-1 antibody may be used for the localization of VEGF-R1 using various immunochemical assays such as ELISA, immunoblotting, immunocytochemistry, immunohistochemistry, and immunoprecipitation. Antibodies that react specifically with VEGF receptors are useful for the study of the specific differential tissue expression and intracellular localization of the receptor in normal and neoplastic tissue.

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