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V6130 Sigma

Vasoactive Intestinal Peptide human, porcine, rat

synthetic, ≥95% (HPLC), powder

Synonym: VIP

  • CAS Number 40077-57-4

  • Empirical Formula (Hill Notation) C147H238N44O42S

  • Molecular Weight 3325.80

  •  MDL number MFCD00167535

  •  PubChem Substance ID 24900760

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Gastrointestinal Peptides, Neuropeptides, Peptides and Proteins,
biological source   synthetic
InChI Key   HEOYHMUESMJFDC-RIWXPGAOSA-N
assay   ≥95% (HPLC)
form   powder
solubility   1% acetic acid: soluble, clear, colorless
storage temp.   −20°C
Gene Information   human ... VIP(7432)

Description

Amino Acid Sequence

His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2

Other Notes

Lyophilized from 0.1% TFA in H2O

Preparation Note

Vasoactive Intestinal Peptide human, porcine, rat dissolves in distilled water and1% acetic acid to yield a clear, colorless solution.

Application

Vasoactive Intestinal Peptide human, porcine, rat was used to treat human donor corneoscleral explants to maintain corneal endothelial (CE) integrity during eye banking. The product was also used as a test compound for studying its impact on swimbladder blood flow by using saline- or blood-perfused swimbladder preparations of the freshwater European eel Anguilla Anguilla.

Biochem/physiol Actions

Neuropeptide that is widely distributed in the central and peripheral nervous systems. It is a vasodilator, bronchodilator and smooth muscle relaxant. It modulates the activity of many immune system cell types. It is a mitogen for embryonic sympathetic neurons. Its neuroprotective actions are mediated by the release of activity-dependent neurotrophic factors from glial cells.

Vasoactive Intestinal Peptide human, porcine, rat (VIP) is a neuropeptide synthesized in the central nervous system that enhances the formation of adenosine 3′,5′-cyclic monophosphate in cerebral cortex and hypothalamus of chick and rat. VIP modulates the cholinergic as well as serotonergic neurotransmitter systems.

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