• USA Home
  • V6633 - VEGF Receptor-3 (Flt-4)/Fc Chimera from mouse

EMAIL THIS PAGE TO A FRIEND
V6633 Sigma

VEGF Receptor-3 (Flt-4)/Fc Chimera from mouse

>95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder

Synonym: Vascular Endothelial Growth Factor Receptor‑3

Purchase

Description

Analysis Note

The activity is measured by its ability to bind human VEGF-D.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

Application

VEGF Receptor-3 (Flt-4)/Fc Chimera from mouse is a disulfide-linked homodimeric protein consist of VEGF Receptor-3 fused with6X histidine tagged Fc portion of human IgG1 by a polypeptide linker. It may be used as a specific marker for lymphatic vessels as well as plays a pivotal role in the development of the lymphatic vessel system. The product was used to study the novel technique for pharmacological manipulation of blood and lymphatic vascularization in cultured mouse embryos ex vivo.

Biochem/physiol Actions

VEGF Receptor-3 (Flt-4) belongs to class III subfamily of RTKs and is expressed mainly in endothelial cells. VEGF Receptor-3 can block VEGF-C/D and inhibits lymphangiogenesis and lymphatic metastasis in orthotopic urinary bladder cancer (OUBC).

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

Set your institution to view full text papers.
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?