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Binds to tubulin and arrests the cell cycle in metaphase by preventing tubulin polymerization and depolymerizing previously formed microtubule.
Semisynthetic derivative of the antineoplastic vinblastine.
Joel, S. Cancer Treat. Rev. 21, 513, (1995)
Heterogeneity of chemosensitivity in six clonal cell lines derived from a spontaneous murine astrocytoma and its relationship to genotypic and phenotypic characteristics. Bradford, R., et al. J. Neurooncol. 34, 247, (1997)
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