|Related Categories||Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors,|
|Gene Information||human ... GABBR1(2550), GABBR2(9568), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)|
Irreversible GABA transaminase inhibitor. Increases intracellular concentration of GABA in nerve endings; possesses antiepileptic activity.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. V8261.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36/37/38|
|Safety Statements (Europe)||26-36|
Fast synaptic transmission requires a mechanism for rapid removal of transmitter molecules from the synaptic cleft, a task most often accomplished by transmitter clearance or degradation. High affini...
GABAA receptors are responsible for the majority of neuronal inhibition in the mammalian CNS. Agonist activation results in the opening of their integral anion channel, generally leading to hyperpola...
Keywords: Anticonvulsants, Central Nervous System, Cloning, Gene expression, Ligands, Neurotransmitters, Phosphorylations, Schizophrenia, Transduction
Glutamine is a common precursor for the biosynthesis of both glutamate and GABA. Glutamine can be transported in and out of neurons and astrocytes utilizing different glutamine carriers. Three such c...
Keywords: Anticonvulsants, Catalysis, Citric Acid Cycle, Gene expression, Metabolism, Neurotransmitters, Nuclear magnetic resonance spectroscopy, Schizophrenia, Spectroscopy, Transaminations
The effect of chronic treatment with the GABA transaminase inhibitors gamma-vinyl-GABA and ethanolamine-O-sulphate on the in vivo release of GABA from rat hippocampus. Qume, M., et al. J. Neurochem. 64, 2256, (1995)
A multisite, double-blind, placebo-controlled clinical trial to evaluate the safety and efficacy of vigabatrin for treating cocaine dependence. Somoza EC, Winship D, Gorodetzky CW, et al. JAMA Psychiatry 70(6), 630-7, (2013)
Probing the steric requirements of the γ-aminobutyric acid aminotransferase active site with fluorinated analogues of vigabatrin. Juncosa JI, Groves AP, Xia G, et al. Bioorg. Med. Chem. 21(4), 903-11, (2013)
Ohtahara syndrome or early-onset West syndrome? A case with overlapping features and favorable response to vigabatrin. Korff CM, Vulliemoz S, Picard F, et al. Eur. J. Paediatr. Neurol. 16(6), 753-7, (2012)
Sildenafil influences the anticonvulsant activity of vigabatrin and gabapentin in the timed pentylenetetrazole infusion test in mice. Nieoczym D, Socała K, Luszczki JJ, et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 39(1), 129-35, (2012)
Vigabatrin-induced forced normalization and psychosis--prolongated termination of behavioral symptoms but persistent antiepileptic effect after withdrawal. Weber P, Dill P, and Datta AN Epilepsy Behav. 24(1), 138-40, (2012)
A microdialysis study of oral vigabatrin administration in head injury patients: preliminary evaluation of multimodality monitoring. Carpenter KL, Timofeev I, Nortje J, et al. Acta Neurochir. Suppl. 114, 271-6, (2012)
Evidence-based guideline update: medical treatment of infantile spasms. Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Go CY, Mackay MT, Weiss SK, et al. Neurology 78(24), 1974-80, (2012)
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