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V9134 Sigma

Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 antibody produced in mouse

clone KDR-1, ascites fluid

Synonym: Anti-KDR, Anti-VEGF R-2

Properties

Related Categories Alphabetical Index, Angiogenesis, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology,
species reactivity   human
application(s)   immunohistochemistry (frozen sections): 1:800 using human placenta
  indirect ELISA: suitable
clone   KDR-1, monoclonal
antibody form   ascites fluid
isotype   IgG1
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... KDR(3791)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

recombinant human extracellular domain of VEGFR-2 (KDR).

General description

The antibody reacts specifically with VEGF receptor 2 (KDR) and does not recognize VEGF receptor-1 (Flt1 receptor), VEGF receptor 3 (sFlt4), and PDGF-Rβ.

Application

Monoclonal Anti-Vascular Endothelial Growth Factor Receptor-2 antibody produced in mouse was used for FACS analysis of HUVECs.

Biochem/physiol Actions

Vascular endothelial growth factors receptors (VEGF Rs) are receptor tyrosine kinases that bind to VEGF. VEGF plays an important role in embryonic vasculogenesis, angiogenesis and homeostasis. The binding of VEGF to VEGF R2 results in activation of MAPK, PI3K, PKC, FAK and Src kinase pathways. The biological roles of VEGF R2 include in epithelial cell growth, proliferation, survival, migration, vascular permeability and angiogenesis.

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