|Related Categories||Arachidonic Acid Cascade, Cell Biology, Cell Signaling and Neuroscience, Cyclooxygenase, Enzyme Inhibitors,|
|solubility||DMSO: ≥20 mg/mL|
Wogonin is an anti-inflammatory agent and COX-2 inhibitor, which inhibits the induction of both iNOS and COX-2. Wogonin inhibits COX-2 (IC50 = 46 μM) without affecting COX-1. Wogonin inhibits iNOS induction and thus inhibts activation-induced C6 glial cell death. Specifically, Wogonin inhibits NF-kappaB-mediated iNOS induction.
It is well established that the brain can sense and react to peripheral insults through the rapid induction of fever and other neuroendocrine changes in response to events such as infection and tissu...
Scott Hauser, Technology Transfer Specialist, Sigma® Life Science
Biofiles, Vol. 8, No. 19
Keywords: Adhesion, Biofiles, Central Nervous System, Diseases, Events, Gene expression, Inflammation, Neurodegenerative Diseases, Reductions, Type
Traditional Chinese Medicine (TCM) is a healing art that has been practiced for thousands of years. The practice of TCM is a holistic approach that includes the use of herbal preparations, acupunctur...
Lynn Stephenson, Product Specialist, Sigma® Life Science and Chloe McClanahan, Product Manager, Sigma Life Science
Biofiles Vol. 8, No. 6
Keywords: Analgesics, Antitumor agents, Apoptosis, Cancer, Drug discovery, Fractionation, High performance liquid chromatography, Metabolites, Metabolomics, Nuclear magnetic resonance spectroscopy, Pharmaceutical
Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial-mediated pathway. Wang CZ, Calway TD, Wen XD, et al. Int. J. Oncol. 42(3), 1018-26, (2013)
[Preparation of flavonoid reference standards from Scutellariae Radix under the guidance of high performance liquid chromatography-mass spectrometry analysis]. Guo H, Yang X, Liu J, et al. Se Pu 30(7), 690-5, (2012)
Development of simultaneous analysis for marker constituents in Hwangryunhaedok-tang () and its application in commercial herbal formulas. Kim SG, Poudel A, Kim YK, et al. J. Nat. Med. 67(2), 390-8, (2013)
Quantitative analysis of anti-inflammatory activity of orengedokuto: importance of combination of flavonoids in inhibition of PGE2 production in mouse macrophage-like cell line J774.1. Oshima N, Narukawa Y, Hada N, et al. J. Nat. Med. 67(2), 281-8, (2013)
Simultaneous determination of baicalin, wogonoside, baicalein, wogonin, oroxylin A and chrysin of Radix scutellariae extract in rat plasma by liquid chromatography tandem mass spectrometry. Tong L, Wan M, Zhang L, et al. J. Pharm. Biomed. Anal. 70, 6-12, (2012)
Wogonin induces cross-regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells. Chow SE, Chen YW, Liang CA, et al. J. Cell. Biochem. 113(11), 3476-85, (2012)
Natural inhibitors of indoleamine 3,5-dioxygenase induced by interferon-gamma in human neural stem cells. Chen S, Corteling R, Stevanato L, et al. Biochem. Biophys. Res. Commun. 429(1-2), 117-23, (2012)
A novel process related impurity and forced degradation study of synthetic wogonin: development of a liquid chromatographic method for purity control. Xia Y, Wu C, Liu W, et al. J. Pharm. Biomed. Anal. 71, 168-72, (2012)
Comparative study of the effect of baicalin and its natural analogs on neurons with oxygen and glucose deprivation involving innate immune reaction of TLR2/TNFα. Li HY, Hu J, Zhao S, et al. J. Biomed. Biotechnol. 2012, 267890, (2012)
[Wogonin inhibits IGF-1-stimulated cell growth and estrogen receptor α expression in breast adenocarcinoma cell and angiogenesis of chick chorioallantoic membrane]. Ma X, Xie KP, Shang F, et al. Sheng Li Xue Bao 64(2), 207-12, (2012)
Phorbol ester or epidermal growth-factor-induced MUC5AC mucin gene expression and production from airway epithelial cells are inhibited by apigenin and wogonin. Kim JO, Sikder MA, Lee HJ, et al. Phytother Res. 26(12), 1784-8, (2012)
Effect of wogonin, a plant flavone from Scutellaria radix, on the suppression of cyclooxygenase-2 and the induction of inducible nitric oxide synthase in lipopolysaccharide-treated RAW 264.7 cells. Chi, et al. Biochem. Pharmacol. 61, 1195-1203, (2001)
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