Wogonin hydrate
≥98% (HPLC), solid
DOWNLOAD MSDS (PDF)Synonym:
5,7-
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CAS Number 632-85-9 (anhydrous)
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Empirical Formula (Hill Notation) C16H12O5 · xH2O
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Molecular Weight 284.26 (anhydrous basis)
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MDL number MFCD12828871
Properties
| Related Categories | Arachidonic Acid Cascade, Cell Biology, Cell Signaling and Neuroscience, Cyclooxygenase, Enzyme Inhibitors, |
| assay | ≥98% (HPLC) |
| form | solid |
| solubility | DMSO: ≥20 mg/mL |
| storage temp. | 2-8°C |
Description
Biochem/physiol Actions
Wogonin is an anti-inflammatory agent and COX-2 inhibitor, which inhibits the induction of both iNOS and COX-2. Wogonin inhibits COX-2 (IC50 = 46 μM) without affecting COX-1. Wogonin inhibits iNOS induction and thus inhibts activation-induced C6 glial cell death. Specifically, Wogonin inhibits NF-kappaB-mediated iNOS induction.
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