|Related Categories||Antagonists, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,|
|solubility||H2O: soluble25 mg/mL|
|Gene Information||human ... HTR1A(3350)|
WAY-100635 maleate salt is a highly selective 5-HT1A serotonin receptor antagonist.
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≥98% (HPLC), solid
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Serotonin (5-hydroxytryptamine, 5-HT) is widely distributed throughout the mammalian body, being synthesized from L-tryptophan in enterochromaffin cells of the gastro-intestinal tract as well as in s...
Keywords: Active transport, Atomic absorption spectroscopy, Cancer, Clinical, Gene expression, Ligands, Neurotransmitters, Obesity, Polymorphisms, Schizophrenia, Transduction
Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist. Fletcher, A., et al. Behav. Brain Res. 73, 337, (1996)
In vivo intrinsic efficacy of the 5-HT1A receptor antagonists NAD-299, WAY-100,635 and (S)-(-)-UH-301 at rat brain monoamine receptors. Ahlenius, S., et al. Eur. Neuropsychopharmacol. 9, 15-19, (1999)
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