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What’s Wrong with My Mouse Behavioral Phenotyping of Transgenic and Knockout Mice

  •  ISBN-10 0-471-31639-3

  •  ISBN-13 978-0-471-31639-8

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Related Categories Biochemistry Books, Books and Software, Cell Signaling Books, Labware
publication info   J.N. Crawley, Wiley-Liss, 2000, 368 pp., hard cover
mfr. no.   Wiley

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General description

This concise review explains the differences between transgenic and knockout mice and their wild-type controls, while providing critical information about gene function and expression. Newly identified genes can provide insights into brain malfunctioning in disease states. It discusses how to generate a transgenic or knockout mouse, functions (open field, holeboard, rotarod, balance, grip, circadian activity, etc.), sensory abilities (olfaction, vision, hearing, taste, touch, nociception), reproductive behavior, social behavior, and emotional behavior.

Table of Contents

1. Designer Mice: Scope and Sourcebooks.  
2. Of Unicorns and Chimeras: How to Generate a Transgenic or Knockout Mouse.
3. General Health: Give Your Mouse a Physical; Neurological Reflexes.  
4. Motor Functions: Open Field, Holeboard, Rotarod, Balance, Grip, Circadian Activity, Circling, Stereotypy, Ataxic Gait, Seizures.
5. Sensory Abilities: Olfaction, Vision, Hearing, Taste, Touch, Nociception.  
6. Learning and Memory: Morris Swim Task, Spatial Mazes, Cued and Contextual Conditioning, Conditioned Taste Aversion, Conditioned Eye Blink, Olfactory Discrimination, Social Recognition, Passive Avoidance, Schedule Controlled Operant Tasks, Motor Learning.
7. Feeding and Drinking: Daily Consumption, Restricted Access, Choice Tests, Microstructural Analysis.  
8. Reproductive Behaviors: Sexual and Parental Behaviors.  
9. Emotional Behaviors: Animal Models of Psychiatric Disorders: Fear, Anxiety, Depression, Schizophrenia.  
10. Reward: Self-Administration of Additive Drugs, Conditioned Place Preference.  
11. The Next Generation: Conditional and Inducible Mutations, Quantitative Trait Loci Analysis, Chemical Mutagenesis, Gene Therapy, Ethical Issues.
Bibliography.  
Index.    

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