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W4270 Sigma

WKYMVM trifluoroacetate salt

≥98% (HPLC)

Synonym: Trp-Lys-Tyr-Met-Val-L-Met NH2 trifluoroacetate salt

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics More...
InChI Key   MYVYQWVNXDVTBW-CZPFDPCBSA-N
assay   ≥98% (HPLC)
form   powder
color   white to off-white
solubility   H2O: >2 mg/mL
shipped in   wet ice
storage temp.   −20°C

Description

Amino Acid Sequence

Trp-Lys-Tyr-Met-Val-L-Met NH2

Packaging

1 mg in glass bottle

Preparation Note

WKYMVM trifluoroacetate salt dissolves in water at a concentration >2 mg/mL to yield a clear solution.

Application

WKYMVM trifluoroacetate salt was used as a test compound for investigating the mechanism of regulation of lipoprotein-associated phospholipase A2 (Lp-PLA2).

Biochem/physiol Actions

WKYMVM is a peptide agonist of formyl peptide receptors. WKYMVM binds to and stimulates FPRL family members 1, 2 with EC50 values of 2 and 80 nM, respectively. The peptide is a potent activator of neutrophils.

WKYMVM is an agonist and potent activator of Formyl peptide receptor like-1 (FPRL1). WKYMVM stimulates FPRL1 and hence attenuates the function of the chemokine receptors CCR5 and CXCR4. WKYMVM activates human eosinophils to induce superoxide production through Phosphoinositide 3-Kinase-Mediated ERK1/2 pathway.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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