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Z0134 Sigma

Anti-Zip Kinase antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology,
species reactivity   human
application(s)   microarray: suitable
  western blot: 0.5 μg/mL using human HeLa cell extract
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 52 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... DAPK3(1613)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 279-298 of an internal domain of human ZIP kinase

General description

Zipper-interacting protein kinase (also known as Dlk) is almost 81% homologous to death-associated protein kinase (DAP). Overexpression of this serine-threonine kinase induces apoptosis. Homodimerization of leucine zipper at the C-terminal leads to the activation of ZIP kinase. Activated ZIP kinase interacts with ATF-4, an oxidative stress-inducible transcription factor. ZIP kinase is also reported to interact with Par-4, a protein that modulates WT1 and results in reorganization of actin filaments and morphological changes associated with apoptosis. Anti-ZIP kinase specifically recognizes human ZIP kinase (52 kDa).

Physical form

Solution in phosphate buffered saline, containing 0.02% sodium azide.

Specificity

The antibody recognizes ZIP kinase, a serine/threonine kinase which possesses a leucine zipper that mediates interaction with transcription factor ATF-4, hence its name. Due to its homology to DAP kinase, it was also named DAP like kinase, Dlk.

Application

Anti-ZIP kinase may be used in immunoblotting applications at a working dilution of 1:1000 or 0.5 μg/mL using HeLa whole cell lysates. The antibody is also suitable for protein microarray.

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Safety Information

RIDADR  NONH for all modes of transport
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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
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References

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