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Z705586 Sigma

Preparative Chromatography of Fine Chemicals and Pharmaceutical Agents

  •  ISBN-10 3-52730643-9

  •  ISBN-13 978-3-52730643-5

Properties

publication info   H. Schmidt-Traub, ed., John Wiley & Sons, 2006, 485 pp., hard cover
mfr. no.   Wiley

Description

General description

High performance adsorbents prepared the ground for increasing applications of preparative chromatography in the field of fine chemicals and pharmaceutical agents. But a real breakthrough was stimulated by additional research and development in the field of continuous separation processes like Simulated Moving Bed technology (SMB). The contents of this book start with an introductory section and go on to explain fundamentals and to define the general terminology. Other sections are on solid materials and packed columns followed by procedures to select chromatographic systems for given tasks and a characterisation of process concepts for batch as well as continuous operation. Subsequent chapters focus on modelling and process simulation including determination of model parameters as well as the design and optimization of preparative chromatographic processes and close with design and operation of chromatographic reactors.

Table of Contents

1 Introduction
1.1 Liquid Chromatography – its History.
1.2 Focus of the Book.
1.3 How to Read this Book.
2 Fundamentals and General Terminology .
2.1 Principles of Adsorption Chromatography.
2.2 Basic Effects and Chromatographic Definitions.
2.3 Fluid Dynamics.
2.4 Mass Transfer Phenomena.
2.5 Equilibrium Thermodynamics.
2.6 Thermodynamic Effects on Mass Separation.
2.7 Practical Aspects of Parameter Determination.
3 Columns,Packings and Stationary Phases
3.1 Column Design.
3.2 Column Packings.
3.3 Column Packing Technology.
3.4 Column Testing.
3.5 Column Maintenance and Regeneration.
3.6 Guidelines for Choosing Chromatographic Columns and Stationary Phases.
4 Selection of Chromatographic Systems
4.1 Definition of the Task.
4.2 Properties of Chromatographic Systems.
4.3 Criteria for Choice of Chromatographic Systems.
5 ProcessConcepts .
5.1 Design and Operation of Equipment.
5.2 Discontinuous Processes.
5.3 Continuous Processes.
5.4 Guidelines.
6 ModelingandDetermination of Model Parameters .
6.1 Introduction.
6.2 Models for Single Chromatographic Columns.
6.3 Modeling HPLC Plants.
6.4 Numerical methods.
6.5 Parameter Determination.
6.6 Validation of Column Models.
6.7 Modeling of SMB Processes.
7 ModelBasedDesign and Optimization .
7.1 Basic Principles.
7.2 Batch chromatography.
7.3 SMB Chromatography.
7.4 Comparison of Batch and SMB Chromatography.
8 Chromatographic Reactors .
8.1 Introduction.
8.2 Types of Chromatographic Reactors.
8.3 Modeling of Chromatographic Reactors.
8.4 Operation and Design of Chromatographic Reactors.
8.5 Design Examples.
9 AdvancedControl of Simulated Moving Bed Processes .
9.1 Introduction.
9.2 Model Predictive Control.
9.3 State-of-the-art in Control of SMB Processes.
9.4 Online Optimizing Control of a Reactive Simulated Moving Bed Process.
9.5 Conclusions.
Outlook. References.
Appendix A.
A1 Scale-up Factors Between Different Columns.
A.2 Standard Operating Procedures for Column Packing.
Appendix B: Data of Test Systems.
B.1 EMD53986.
B.2 Tröger’s Base.
B.3 Glucose and Fructose.
B.4 g -Phenethyl Acetate.
Index.

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