• USA Home
  • Z730246 - HPLC for Pharmaceutical Scientists

EMAIL THIS PAGE TO A FRIEND
Z730246 Sigma

HPLC for Pharmaceutical Scientists

Y. Kazalevich and R. Lobrutto, ed., John Wiley & Sons, 2007, 1104 pp., hard cover

  •  ISBN-13 978-0-471-68162-5

Purchase

Properties

Related Categories Books and Software, Chromatography Books, Labware More...
publication info   Y. Kazalevich and R. Lobrutto, ed., John Wiley & Sons, 2007, 1104 pp., hard cover
mfr. no.   Wiley

Description

General description

HPLC for Pharmaceutical Scientists is an excellent book for pharmaceutical chemists who regularly use HPLC as an analytical tool to solve challenging problems in the pharmaceutical industry. It provides a unified approach to HPLC with an equal and balanced treatment of the theory and practice of HPLC in the pharmaceutical industry. In-depth discussion of retention processes, modern HPLC separation theory, properties of stationary phases and columns are well blended with the practical aspects of fast and effective method development and method validation. Practical and pragmatic approaches and actual examples of effective development of selective and rugged HPLC methods from a physico-chemical point of view are provided. This book elucidates the role of HPLC throughout the entire drug development process from drug candidate inception to marketed drug product and gives detailed specifics of HPLC application in each stage of drug development. The latest advancements and trends in hyphenated and specialized HPLC techniques (LC-MS, LC-NMR, Preparative HPLC, High temperature HPLC, high pressure liquid chromatography) are also discussed.

Table of Contents

PART I HPLC THEORY AND PRACTICE.
1 Introduction
2 HPLC Theory
3 Stationary Phases
4 Reversed-Phase HPLC
5 Normal-Phase HPLC
6 Size-Exclusion Chromatography
7 LC/MS: Theory, Instrumentation, and Applications to Small Molecules .
8 Method Development
9 Method Validation
10 Computer-Assisted HPLC and Knowledge Management
PART II HPLC IN THE PHARMACEUTICAL INDUSTRY.
11 The Expanding Role of HPLC in Drug Discovery
12 Role of HPLC in Preformulation
13 The Role of Liquid Chromatography–Mass Spectrometry in Pharmacokinetics and Drug Metabolism
14 Role of HPLC in Process Development .
14.1 Responsibilities of the Analytical Chemist During Process Development.
14.2 HPLC Separation Modes.
14.3 Sample Preparation.
14.4 HPLC Detectors.
14.5 Method Development.
14.6 In-Process Monitoring.
14.7 Impurity Identification.
14.8 Establishment of HPLC Selectivity by Stress Studies.
14.9 HPLC Method Validation.
14.10 Technology Transfer.
14.11 Concluding Remarks.
15 Role of HPLC During Formulation Development ).
15.1 Introduction.
15.2 Prerequisite for Analytical Chemists During Formulation Development.
15.3 Properties of Drug Substance.
15.4 Properties of Excipients.
15.5 Impact of Excipients on Degradation of API(s).
15.6 Test Methods for Most Common Dosage Forms in which HPLC Is the Primary Technique.
15.7 Forced Decomposition.
15.8 Compatibility of Excipients with API(s) (Type and Ratio).
15.9 Mass Balance.
15.10 Summary of Assay and Related Substances.
15.11 Uniformity of Dosage Units.
15.12 Blend Uniformity (BU).
15.13 Cleaning Verification.
15.14 Extractables/Leachables.
15.15 Dissolution.
15.16 Method Development.
15.17 Method Validation.
15.18 Testing of Samples.
15.19 Automation Opportunities.
15.20 Implementation of Alternative Technologies.
15.21 Challenges and Future Trends.
16 The Role of HPLC in Technical Transfer and Manufacturing
PART III HYPHENATED TECHNIQUES AND SPECIALIZED HPLC SEPARATIONS.
17 Development of Fast HPLC Methods.
18 Temperature as a Variable in Pharmaceutical Applications .
19 LC/MS Analysis of Proteins and Peptides in Drug Discovery
20 LC-NMR Overview and Pharmaceutical Applications
21 Trends in Preparative HPLC .
22 Chiral Separations
CHEMICAL AND DRUG COMPOUND INDEX.
SUBJECT INDEX.

Price and Availability

Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

Protocols & Articles
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?