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52769-U Supelco

SupelMIP® SPE - NSAIDs

bed wt. 25 mg, volume 3 mL, pk of 50

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Properties

Related Categories Analytical/Chromatography, Sample Preparation & Purification, Solid Phase Extraction (SPE), SupelMIP Molecular Imprinted Polymers, SupelMIP SPE - NSAIDS More...
composition   bed wt., 25 mg
packaging   pk of 50
volume   3 mL
matrix active group   SupelMIP® phase

Description

Application

Developed and optimized for the extraction of non-steroidal anti-inflammatory drugs (NSAIDs) from aqueous samples such as drinking and waste water.

The NSAIDs that we have tested so far include: Naproxen, Clofibric Acid, Diclofenac, and Ibuprofen. The SupelMIP SPE - NSAIDs phase is compatible with other non-carboxylic acid anti-inflammatory drugs such as Piroxicam and Celecoxib; however, lower recovery (40-60%) may occur.

Features and Benefits

• Highly selective SPE for trace analysis in complex matrices
• Achieve lower detection limits
• Significant time and cost savings
• Improved MS-compatibility

General description

SupelMIP SPE phases were developed by MIP Technologies AB, which is one of the leading authorities and commercial pioneers of molecular imprinted polymers for process scale separations, analytical chromatography, and sample preparation.

The SupelMIP SPE line consist s of highly cross-linked polymers that are engineered to extract a single analyte of interest or a class of structurally related analytes with an extremely high degree of selectivity. This is possible because selectivity is introduced during MIP synthesis in which a template molecule, designed to mimic the analyte, guides the formation of specific cavities or imprints that are sterically and chemically complementary to the analyte(s) of interest.

By careful design of the imprinting site, either by molecular modeling, experimental design, or screening methods, the binding cavities can be engineered to offer multiple interaction points with the analyte(s) of interest. This leads to a stronger interaction between the solid-phase and the analyte(s). As a consequence, harsher wash conditions can be tolerated during SPE methodology resulting in cleaner extracts. Because extraction selectivity is significantly improved, lower background is observed allowing analysts to achieve lower limits of detection.

Visit www.sigma-aldrich.com/supelmip to learn more.

Legal Information

SupelMIP is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability


Pharma QC

All labs need water
Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.

Documents

Certificate of Analysis

Protocols & Articles

Articles

Molecularly Imprinted Polymer SPE- Acid NSAIDs from Muscle

The determination of acidic pharmaceuticals, such as nonsteroidal anti-inflammatory drugs (NSAIDs), at low levels in muscle tissue requires highly selective and sensitive analytical procedures. Final...
Dr. Anja Siewing
Reporter US, Volume 29 Number 1
Keywords: Anti-inflammatory agents, Food Safety, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolites, Pharmaceutical, Sample preparations, Separation, Solid phase extractions, Veterinary

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