142662
Aldrich

Chlorosulfonyl isocyanate

98%

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1 of 1

Synonym

N-Carbonylsulfamyl chloride

CSI

Molecular Formula

ClSO₂NCO

Molecular Weight

141.53

CAS Number

1189-71-5

Beilstein Registry Number

1237247

MDL number

MFCD00011608

PubChem Substance ID

24848531

EG/EC Number

214-715-2

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Descriptions

Application

Employed in a regio- and diastereoselective introduction of a protected amino group in a synthesis of chiral, polyhydroxylated piperidines.¹ Generation of ureas from amino groups in a synthesis of benzimidazolones.²

Synthetically versatile reagent³ for the preparation of amides,⁴ lactams,^5,⁶ and triazocinones.⁷

Packaging

1 kg in glass btl

25, 100 g in glass btl

Properties

vapor pressure

5.57 psi ( 20 °C)

assay

98%

refractive index

n20/D 1.447(lit.)

107 °C(lit.)

−44 °C(lit.)

density

1.626 g/mL at 25 °C(lit.)

Gene Information

human ... ABCB1(5243), FPR1(2357)

References

Cited Reference

1. Tetrahedron Lett. 47, 7289, (2006)

2. Tetrahedron Lett. 47, 129, (2006)

3. Aldrichimica Acta 10, 23, (1977)

4. J. Org. Chem. 58, 7022, (1993)

5. Synlett, 539, (1994)

6. Synth. Commun. 22, 2729, (1992)

7. Synth. Commun. 23, 2151, (1993)

Beilstein

Beil. 3,IV,86

Fieser

Fieser 1,117 / Fieser 2,70 / Fieser 3,51 / Fieser 4,90 / Fieser 5,132 / Fieser 6,122 / Fieser 7,65 / Fieser 8,105 / Fieser 10,94 / Fieser 11,125 / Fieser 12,122 / Fieser 13,80

reference

Aldrich MSDS 1, 458:D / Corp MSDS 1 (1), 859:A / FT-IR 2 (1), 1536:A / FT-IR 1 (1), 902:D / IR-Spectra (3), 543:A / IR-Spectra (2), 480:E / RegBook 1 (1), 1081:K / Sax 6, 775 / Sigma FT-IR 1 (2), 396:B / Vapor Phase 3, 836:A

Safety

Hazard Codes

Risk Statements

14-22-34-42

Safety Statements

23-26-30-36/37/39-45

RIDADR

UN 3265 8/PG 2

WGK Germany

10-21-19