B103608
Aldrich

γ-Butyrolactone

ReagentPlus^®, ≥99%

zoom

1 of 1

Synonym

γ-Hydroxybutyric acid lactone

4-Hydroxybutyric acid lactone

GBL

Molecular Formula

C₄H₆O₂

Molecular Weight

86.09

CAS Number

96-48-0

Beilstein Registry Number

105248

MDL number

MFCD00005386

PubChem Substance ID

24891553

EG/EC Number

202-509-5

Expand/Collapse All

Descriptions

Packaging

20 kg in VerSA-Flow™

20 kg packaged in closed-head composite drums; 25 g, 500 g, 3 kg packaged in glass bottles

25, 500 g in glass btl

3 kg in glass btl

Application

For the introduction of 3-carboxypropyl side chain.¹ Used as a component of electrolyte solutions in batteries and capacitors.²

Biochem/physiol Actions

Precursor of γ-hydroxybutyric acid (GHB). It blocks dopamine release by blocking impulse flow in dopaminergic neurons. Pretreatment with γ-butyrolactone allows detection of autoreceptor-induced dopamine release.

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Biotechnology LP and Sigma-Aldrich Co.

Properties

grade

ReagentPlus^®

vapor density

3 (vs air)

vapor pressure

1.5 mmHg ( 20 °C)

assay

≥99%

autoignition temp.

851 °F

expl. lim.

16 %

refractive index

n20/D 1.436(lit.)

204-205 °C(lit.)

−45 °C(lit.)

density

1.12 g/mL at 25 °C(lit.)

References

Cited Reference

1. J. Med. Chem. 34, 267, (1991) abstract

2. J. Power Sources 43, 195, (1993)

Reference

Ohkawa, S., et al., Dual inhibitors of thromboxane A2 synthase and 5-lipoxygenase with scavenging activity of active oxygen species. Synthesis of a novel series of (3-pyridylmethyl)benzoquinone derivatives. J. Med. Chem. 34, 267-276, (1991)

Koeltzow, T.E., Alterations in dopamine release but not dopamine autoreceptor function in dopamine D3 receptor mutant mice. J. Neurosci. 18, 2231, (1998)

Walters, J.R., and Roth, R.H., Dopaminergic neurons: drup-induced antagonism of the increase in tyrosine hydroxylase activity produced by cessation of impulse flow. J. Pharmacol. Exp. Ther. 191, 82-91, (1974)

Merck

Merck 13,1596

Beilstein

Beil. 17,V,9,7

Fieser

Fieser 1,101

reference

Aldrich MSDS 1, 337:A / Arctander, 552 / Corp MSDS 1 (1), 656:A / FT-IR 2 (1), 1174:A / FT-IR 1 (1), 697:D / FT-NMR 1 (1), 1127:A / Fenaroli, 99 / IR-Spectra (3), 407:F / IR-Spectra (2), 360:H / NMR-Reference 2 (1), 590:C / RegBook 52 (1), 803:J / RegBook 1 (1), 803:J / Sax 6, 549 / Sigma FT-IR 1 (2), 623:A / Structure Index 1, 125:D:6 / Vapor Phase 3, 749:A

Safety

Hazard Codes

Risk Statements

22-36

Safety Statements

WGK Germany

RTECS

LU3500000

UEL

16.00%

LEL

1.40%