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MilliporeSigma

W308307

Triethyl citrate

≥99%, FCC, FG

Synonym(s):

Ethyl citrate

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$57.20

1 KG

$117.00

10 KG

$556.00

25 KG

$980.00

$57.20

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About This Item

Linear Formula:
HOC(COOC2H5)(CH2COOC2H5)2
CAS Number:
77-93-0
Molecular Weight:
276.28
FEMA Number:
3083
Beilstein/REAXYS Number:
1801199
EC Number:
201-070-7
Council of Europe no.:
11762
MDL number:
MFCD00009201
UNSPSC Code:
12164502
PubChem Substance ID:
24901458
Flavis number:
9.512
NACRES:
NA.21
Organoleptic:
odorless
Grade:
FG
Halal
Kosher
Biological source:
synthetic
Agency:
meets purity specifications of JECFA
Food allergen:
no known allergens

Key Documents

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biological source

synthetic

Quality Level

300
400

grade

FG
Halal
Kosher

agency

meets purity specifications of JECFA

reg. compliance

EU Regulation 1334/2008 & 872/2012
FCC
FDA 21 CFR 117
FDA 21 CFR 175.300
FDA 21 CFR 175.320
FDA 21 CFR 181.27
FDA 21 CFR 184.1911

vapor density

9.7 (vs air)

vapor pressure

1 mmHg ( 107 °C)

assay

≥99%

refractive index

n20/D 1.442 (lit.)

bp

235 °C/150 mmHg (lit.)

density

1.14 g/mL at 25 °C (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

organoleptic

odorless

SMILES string

CCOC(=O)CC(O)(CC(=O)OCC)C(=O)OCC

InChI

1S/C12H20O7/c1-4-17-9(13)7-12(16,11(15)19-6-3)8-10(14)18-5-2/h16H,4-8H2,1-3H3

InChI key

DOOTYTYQINUNNV-UHFFFAOYSA-N

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Show Differences

1 of 4

This Item
27500PHR11538.17059
Triethyl citrate ≥99%, FCC, FG

Sigma-Aldrich

W308307

Triethyl citrate

Triethyl citrate ≥98.0% (GC)

Sigma-Aldrich

27500

Triethyl citrate

Triethyl citrate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1153

Triethyl citrate

Triethyl citrate EMPROVE® ESSENTIAL, Ph. Eur., ChP, JPE, NF

SAFC

8.17059

Triethyl citrate

organoleptic

odorless

organoleptic

-

organoleptic

-

organoleptic

-

grade

FG, Kosher, Halal

grade

-

grade

certified reference material, pharmaceutical secondary standard

grade

-

biological source

synthetic

biological source

-

biological source

-

biological source

-

food allergen

no known allergens

food allergen

-

food allergen

-

food allergen

-

agency

meets purity specifications of JECFA

agency

-

agency

traceable to USP 1683606

agency

ChP, JPE, NF, Ph. Eur.

assay

≥99%

assay

≥98.0% (GC)

assay

-

assay

-

General description

Triethyl citrate can be used as a plasticizer and sequestrant in the food industry.[1][2]

Application


  • Cosmetically Approved Short-Chain Alcohol/Triethyl Citrate/Water Surfactant-Free Microemulsions and Potential Application to Transdermal Penetration of α-Arbutin.: This study investigates the formulation of surfactant-free microemulsions using triethyl citrate, exploring its potential in enhancing the transdermal penetration of α-arbutin. The results suggest significant improvement in skin delivery, highlighting the cosmetic and pharmaceutical potential of triethyl citrate (Zhang et al., 2024).

  • Understanding the Interaction of Thermal, Rheological, and Mechanical Parameters Critical for the Processability of Polyvinyl Alcohol-Based Systems during Hot Melt Extrusion.: This research delves into the role of triethyl citrate as a plasticizer in polyvinyl alcohol-based systems, essential for optimizing hot melt extrusion processes. The findings emphasize the importance of precise thermal and mechanical control in pharmaceutical applications (Hess et al., 2024).

  • The effect of additives on the biodegradation of polyhydroxyalkanoate (PHA) in marine field trials.: Triethyl citrate is evaluated as an additive to improve the biodegradation of polyhydroxyalkanoates in marine environments. This study presents its efficacy in enhancing environmental sustainability through accelerated degradation (Read et al., 2024).

  • In-situ forming PLGA implants: Towards less toxic solvents.: Investigating the use of triethyl citrate as a less toxic solvent alternative in PLGA implants, this paper demonstrates its potential in reducing toxicity while maintaining implant efficacy, beneficial for pharmaceutical applications (Ramos et al., 2024).

  • Influence of Low-Molecular-Weight Esters on Melt Spinning and Structure of Poly(lactic acid) Fibers.: This article explores the impact of triethyl citrate on the properties of poly(lactic acid) fibers, highlighting its role in enhancing fiber structure and processability for industrial applications (Gzyra-Jagieła et al., 2024).

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

311.0 °F - closed cup

flash_point_c

155 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SHBT2963
SHBS8555
SHBS7407
SHBS4669
SHBR6145

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Dictionary of Food ingredients, 144-144 (2013)
Food Additives, 682-682 (1999)
Fang Liu et al.
Journal of controlled release : official journal of the Controlled Release Society, 133(2), 119-124 (2008-10-22)
A novel double-coating enteric system was developed to accelerate drug release in conditions resembling the upper small intestine. The system comprises an inner coat (partially neutralised EUDRAGIT L 30 D-55 and organic acid) and an outer coat (standard EUDRAGIT L
Claire Gendre et al.
International journal of pharmaceutics, 421(2), 237-243 (2011-10-11)
The aim of this work was to carry out real-time near infrared (NIR) predictions of drug release from sustained release coated tablets and to determine end point of coating operation. In-line measurements were ensured by implementation of a NIR probe
T Quinten et al.
AAPS PharmSciTech, 13(4), 1197-1211 (2012-09-12)
Sustained-release matrix tablets based on Eudragit RL and RS were manufactured by injection moulding. The influence of process temperature; matrix composition; drug load, plasticizer level; and salt form of metoprolol: tartrate (MPT), fumarate (MPF) and succinate (MPS) on ease of
View All Related Papers

Questions

1–10 of 11 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Do you supply a USP grade of material? I am not looking for an reference standard. We will use this in the product formula.

    1 answer

    1. Triethyl citrate is not supplied as USP grade material. This product meets purity specifications of JECFA (The Joint FAO/WHO Expert Committee on Food Additives). All available documentation for regulatory purposes can be found under the "Documentation" section of the product's webpage.

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  4. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  5. Is there any alcohol present in Product W308307, Triethyl citrate?

    1 answer

    1. The final product will have alcohol present. It will be less than 0.05 wt %. (ipi)

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  6. What grade is Product W308307, Triethyl citrate, and how do I get the Certificates on this product?

    1 answer

    1. The product W308307 is classified under the following grades: Food grade (FG), FCC, HALAL, Kosher and NI grade. The Certificates are available from our website or contact [email protected] or call 1-800-325-5832.

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  7. How do I convert the solid unit package to liquid volume for Product W308307, Triethyl citrate?

    1 answer

    1. If you divide the package size by the density of Triethyl citrate (1.14 g/ml), you can get the volume amount in that package. Example: 1000 gm/1.14 g/ml which is 877.19 ml.

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  8. What amount is there in the SAMPLE size of Product W308307, Triethyl citrate?

    1 answer

    1. Sample package size contains 10 grams.

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  9. How do I reconstitute Product W308307, Triethyl citrate?

    1 answer

    1. You can reconstitute Triethyl citrate in water at a concentration of 65 g/l. (27500 product pink database)

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  10. What is the form of Product W308307, Triethyl citrate, liquid or solid? How can I find that?

    1 answer

    1. The product W308307 is in a liquid form and this information is found in the specification sheet.

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1–10 of 11 Questions  

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