Combinatorial Chemistry and Molecular Diversity in Drug Discovery 

0471155187

978-047115518-8

E. Gordon, ed., John Wiley & Sons, Ltd, 1998, 516 pp., hard cover

PARTIAL TABLE OF CONTENTS:
COMBINATORIAL CHEMISTRY AND MOLECULAR DIVERSITY: AN INTRODUCTION.
Historical Overview of the Developing Field of Molecular Diversity
Solid-Phase Peptide Synthesis, Lead Generation, and Optimization
Oligonucleotide Libraries as a Source of Molecular Diversity
SMALL MOLECULAR LIBRARIES.
Protease Inhibitor Libraries .
Scaffolds for Small Molecule Libraries
Encoded Combinatorial Chemistry
Parallel Organic Synthesis in Array Format
AUTOMATION, ANALYTICAL, AND COMPUTATIONAL METHODS.
Automation of Combinatorial Chemistry for Large Libraries
Quantifying Diversity
BIOLOGICAL DIVERSITY.
Protein Scaffolds for Peptide Libraries
SCREENING.
Strategies for Screening Combinatorial Libraries
COMBINATORIAL DRUG SCREENING AND DEVELOPMENT.
Combinatorial Technologies: Prospects and Future Issues
Appendix.
Index.