Analysis and Purification Methods in Combinatorial Chemistry 

0-471-26929-8

978-0-471-26929-8

B. Yan, John Wiley & Sons, 2003, 466 pp., hard cover

PART I: ANALYSIS FOR FEASIBILITY AND OPTIMIZATION OF LIBRARY SYNTHESIS.
Chapter 1. Quantitative Analysis in Organic Synthesis with NMR
Chapter 2. ¹⁹F Gel-phase NMR Spectroscopy for Reaction Monitoring and Quantification of Resin Loading
Chapter 3. The Application of Single-Bead FTIR and Color Test for Reaction Monitoring and Building Block Validation in Combinatorial Library Synthesis.
Chapter 4. HR-MAS NMR Analysis of Compounds Attached to Polymer Supports .
Chapter 5. Multivariate Tools for Real-Time Monitoring and Optimization of Combinatorial Materials and Process Conditions .
Chapter 6. Mass Spectrometry and Soluble Polymeric Supports
PART II: HIGH-THROUGHPUT ANALYSIS FOR LIBRARY QUALITY CONTROL.
Chapter 7. High-Throughput NMR Techniques for Combinatorial Chemical Library Analysis
Chapter 8. Micellar Electrokinetic Chromatography as a Tool for Combinatorial Chemistry Analysis: Theory and Applications
Chapter 9. Characterization of Split-Pool Encoded Combinatorial Libraries .
PART III: HIGH-THROUGHPUT PURIFICATION TO IMPROVE LIBRARY QUALITY.
Cha pter 10. Strategies and Methods for Purifying Organic Compounds and Combinatorial Libraries .
Chapter 11. HTP of Combinatorial Chemistry Libraries
Chapter 12. Practical HPLC in High Throughput Analysis and Purification
PART IV: ANALYSIS FOR COMPOUND STABILITY AND DRUGABILITY.
Chapter 13. Organic Compound Stability in Large, Diverse Phatmaceutical Screening Collection
Chapter 14. Quartz Crystal Microbalance in Biomolecular Recognition
Chapter 15. High-Throughput Physicochemical Profiling: Potential and Limitations
Chapter 16. Solubility in the Design of Combinatorial Libraries
Chapter 17. High-Throughput Determination of Log D Values by LC/MS Method
Index.