O-Acetyl-L-carnitine hydrochloride 

Endogenous mitochondrial metabolite that transports acetyl groups across the mitochondrial membrane. Exogenous acetylcarnitine enhances mitochondrial function in aged rats. As an acetate donor to coenzyme A, it increases the central and peripheral acetylcholine synthesis and function. Acetylcarnitine has antinociceptive activity that may be mediated by enhanced activity of muscarinic cholinergic receptors or mGlu2 glutamate receptors.

Transmembrane action potential studies¹

BioChemika

≥99.0% (AT)

[α]20/D −29±1°, c = 1% in H₂O

≤0.5% loss on drying

H₂O: 0.1 g/mL, clear, colorless

1. K. Matsui Jpn. J. Pharmacol. 39, 263, (1985) abstract

Ames, B.N., and Liu, J., Delaying the mitochondrial decay of aging with acetylcarnitine. Ann. N.Y. Acad. Sci. 1033, 108-116, (2004)

Gorini, A., et al., Energy metabolism of synaptosomal subpopulations from different neuronal systems of rat hippocampus: effect of L-acetylcarnitine administration in vivo. Neurochem. Res. 24, 617-624, (1999)

Ando, S., et al., Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats. J. Neurosci. Res. 66, 266-271, (2001)

Ghelardini, C, et al. , Acetyl-l-carnitine induces muscarinic antinocieption in mice and rats. Neuropharmacology 43, 1180-1187, (2002)

Chiechio, S., et al. , Metabotropic receptors as targets for drugs of potential use in the treatment of neuropathic pain. J. Endocrinol. Invest. 27 Suppl. 6, 171-176, (2004)

Xi

36/37/38

26-36

3

3-9