01809
Fluka

Actinonin

BioChemika, ≥99.0% (TLC)

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Synonym

3-[[1-[(2-(Hydroxymethyl)-1-pyrrolidinyl)carbonyl]-2-methylpropyl]carbamoyl]octanohydroxamic acid

Molecular Formula

C₁₉H₃₅N₃O₅

Molecular Weight

385.50

CAS Number

13434-13-4

Beilstein Registry Number

1555250

MDL number

MFCD00080257

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Descriptions

Biochem/physiol Actions

Inhibitor of leucine aminopeptidase.

Other Notes

Aminopeptidase inhibitor^1,²

Properties

product line

BioChemika

assay

≥99.0% (TLC)

References

Cited Reference

1. H. Umezawa et al. J. Antibiot. 38, 1629, (1985) abstract

2. M. Shimamura et al. J. Biochem. 109, 492, (1991) abstract

Reference

Lendeckel, U. et al., Inhibition of alanyl aminopeptidase induces MAP-kinase p42/ERK2 in the human T cell line KARPAS-299. Biochem. Biophys. Res. Commun. 252, 5, (1998)

Sayama, Y., et al., Effects of an antibiotic protease inhibitor, actinonin on the growth within collagen gels of non-metastatic and metastatic mouse mammary tumors of the same. Cancer Lett. 94, 171, (1995)

Xu, Y., et al., Antitumor activity of actinonin in vitro and in vivo. Clin. Cancer Res. 4, 171, (1998)

Safety

Safety Statements

22-24/25

WGK Germany

RTECS

RG9900700

Related Categories

... Antibacterial > A - K

... Antibiotics A to Z > Antibiotics A-F

... Antibiotics by Application > Antineoplastic and Immunosuppressive Antibiotics

... Mechanism of Action > Inhibits an Enzyme

... Chemical Structure Class > Peptides

MSDS

Certificate of Analysis

More Information