01895
Fluka

Adenosine 3′,5′-cyclic monophosphate

BioChemika, ≥99.0% (HPLC)

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Synonym

3′,5′-Cyclic AMP

Adenosine 3′,5′-cyclophosphate

cAMP

Molecular Formula

C₁₀H₁₂N₅O₆P

Molecular Weight

329.21

CAS Number

60-92-4

Beilstein Registry Number

52645

MDL number

MFCD00005845

EG/EC Number

200-492-9

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Descriptions

Other Notes

Intracellular messenger. Binding to cyclic AMP-dependent protein kinase¹

Biochem/physiol Actions

Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.

Properties

product line

BioChemika

assay

≥99.0% (HPLC)

optical activity

[α]20/D −54±2°, c = 0.7% in H₂O

total impurities

≤5% water

260 °C (dec.)(lit.)

storage temp.

2-8°C

References

Cited Reference

1. S.S. Taylor et al. Annu. Rev. Biochem. 59, 971, (1990) abstract

Reference

Chen, T.C., et al., Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab. Invest. 78, 165-174, (1998)

Spada, A., et al., Cyclic AMP and calcium in the transduction of hypothalamic neurohormone action in human pituitary tumors. Horm. Res. 47, 235-239, (1997)

Daniel, P.B., et al., Cyclic AMP signaling and gene regulation. Annu. Rev. Nutr. 18, 353-383, (1998)

Merck

Merck 13,2737

Beilstein

Beil. 26,IV,3618

reference

FT-IR 2 (3), 3691:C / FT-IR 1 (2), 725:A / FT-NMR 1 (3), 229:A / IR-Spectra (3), 1301:F / IR-Spectra (2), 1133:G / NMR-Reference 2 (2), 605:D / RegBook 1 (2), 2481:D / Sigma FT-IR 1 (1), 805:C / Structure Index 1, 392:D:3

Safety

Safety Statements

22-24/25

WGK Germany

RTECS

AU7357600

10-21

Related Categories

... Nucleosides, Nucleotides, Oligonucleotides > Nucleotides

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