12809
Fluka

O-(Benzotriazol-1-yl)-N,N,N′,N′-bis(tetramethylene)uronium hexafluorophosphate

purum, ≥98.0% (TLC)

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Synonym

HBPyU

(Benzotriazol-1-yloxy)dipyrrolidinocarbenium hexafluorophosphate

Molecular Formula

C₁₅H₂₀F₆N₅OP

Molecular Weight

431.32

CAS Number

105379-24-6

MDL number

MFCD00191770

PubChem Substance ID

24847825

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Descriptions

Application

Non-hygroscopic, extremely reactive reagent for peptide coupling giving low racemization. Reaction by-products are non-cytotoxic. Recent studies show that crystal and solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound.

Other Notes

Recent studies show that crystal and solution structure of this coupling agent is a guanidinium N-oxide and not an uronium compound¹; Non-hygroscopic, extremely reactive reagent for peptide coupling giving low racemization. Reaction by-products are non-cytotoxic²

Properties

grade

purum

assay

≥98.0% (TLC)

176 °C (dec.)(lit.)

solubility

acetonitrile: 0.1 g/mL, clear

storage temp.

2-8°C

References

Cited Reference

1. P. Henklein et al. Proc. 24th Eur. Pept. Symp.: Peptides 1996 Kingswinford, UK , 465, (1998)

2. S. Chen, J. Xu Tet. Lett. 33, 647, (1992)

reference

FT-IR 2 (3), 3643:A / Structure Index 1, 387:B:6

Safety

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

10-21

Related Categories

... Coupling > Phosphonium/Uronium/Formamidinium

FT-IR Condensed Phase

MSDS

Certificate of Analysis

More Information