14340
Fluka

(+)-Bicuculline

BioChemika, ≥97.0% (TLC)

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Molecular Formula

C₂₀H₁₇NO₆

Molecular Weight

367.35

CAS Number

485-49-4

Beilstein Registry Number

98786

MDL number

MFCD00005006

PubChem Substance ID

24848584

EG/EC Number

207-619-7

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Descriptions

Biochem/physiol Actions

(+)-Bicuculline is a GABA_A receptor antagonist.

Other Notes

GABA antagonist^1,²

Properties

product line

BioChemika

assay

≥97.0% (TLC)

optical activity

[α]20/D +126±6°, c = 1% in chloroform

193-197 °C

Gene Information

rat ... Gabra2(29706)

References

Cited Reference

1. M.A. Simmonds Neuropharmacology 19, 39, (1980) abstract

2. E. Breuker et al. Br. J. Pharmacol. 58, 458, (1976)

Reference

Avoli, M., et al., Functional and pharmacological properties of GABA-mediated inhibition in the human neocortex. Can. J. Physiol. Pharmacol. 75, 526, (1997)

Johnson, S.W., Seutin, V., Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca²⁺-activated K⁺ currents. Neurosci. Lett. 231, 13, (1997)

Strobaek, D., et al., Pharmacological characterization of small-conductance Ca²⁺-activated K⁺ channels stably expressed in HEK 293 cells. Br. J. Pharmacol. 129, 991, (2000) abstract

Chebib, M., Johnston, G.A., The 'ABC' of GABA receptors: a brief review. Clin. Exp. Pharmacol. Physiol. 26, 937, (1999)

Merck

Merck 13,1207

Beilstein

Beil. 27,IV,6900

Safety

Hazard Codes

T,N

Risk Statements

23/24/25-50

Safety Statements

36/37-45-61