16135
Fluka

8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt

BioChemika, ≥98.0% (HPLC)

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Replaced by

B7880, 8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt

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Synonym

8-Br-cAMP

Molecular Formula

C₁₀H₁₀BrN₅NaO₆P

Molecular Weight

430.08

CAS Number

76939-46-3

Beilstein Registry Number

7739743

MDL number

MFCD00005844

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Descriptions

Other Notes

Membrane-permeable cAMP analog.

Inhibits the transient expression of firefly luciferase¹

Biochem/physiol Actions

Cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.

Properties

product line

BioChemika

assay

≥98.0% (HPLC)

total impurities

≤2% adenosine-3',5'-cyclophosphate (HPLC)

storage temp.

−20°C

References

Cited Reference

1. G.T. Coker et al. FEBS Lett. 249, 183, (1989)

Reference

Martin, T.F., and Kowalchyk, J.A., Growth inhibition by adenosine 3',5-monophosphate derivatives does not require 3',5' phosphodiester linkage. Science 213, 1120-1122, (1981)

Chen, T.C., et al., Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab. Invest. 78, 165-174, (1998)

Hei, Y.J., et al., Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs. Mol. Pharmacol. 39, 233, (1991)

Meyer, R.B. Jr., and Miller, J.P., Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity. Life Sci. 14, 1019-1040, (1974)

Safety

Safety Statements

22-24/25

WGK Germany

10-21

MSDS

Certificate of Analysis

More Information