Capsaicin 

Active component of cayenne pepper

A tool in microbiological research.^1,2

Prototype vanilloid receptor agonist. Neurotoxin; activates sensory neurons that give rise to unmyelinated C-fibers, many of which contain substance P. Topical application desensitizes the sensory nerve endings giving a paradoxical antinociceptive effect; systemic administration can be neurotoxic to capsaicin-sensitive cells, especially in newborn animals.

BioChemika

≥97.0% (HPLC)

62-65 °C(lit.)

65-68 °C

rat ... Trpv1(83810), Trpv4(66026)

human ... CYP1A2(1544), TRPV1(7442)

2-8°C

1. U. Otten et al. Nature 301, 515, (1983) abstract

2. T.L. Yaksh et al. Science 206, 481, (1979) abstract

Holzer, P., Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 24, 739-768, (1988)

Bevan, S., and Szolcsanyi, J., Sensory neuron-specific actions of capsaicin: mechanisms and applications. Trends Pharmacol. Sci. 11, 330-333, (1990)

G. Jancso et al. Nature 270, 741, (1977) abstract

Merck 13,1774

Beil. 13,IV,2588

Arctander, 567 / FT-IR 2 (2), 2985:C / FT-NMR 1 (2), 1378:C / Fenaroli, 364 / RegBook 1 (2), 2009:M / Sax 6, 629 / Structure Index 1, 320:E:8

UN2811 6.1 /PG 3

3

RA8530000

235.4 °F

113 °C