Caffeine 

Pharmacology and toxicology¹

A central nervous system stimulant believed to act through adenosine receptors and monoamine neurotransmitters. It is an adenosine receptor antagonist and adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. Thus, levels of cAMP increase in cells following treatment with caffeine. It has been reported to affect cellular calcium levels, releasing calcium from intracellular stores. It overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.

purum

≥99.0% (HPLC)

233-238 °C

234-236.5 °C(lit.)

human ... ADORA1(134), PDE4B(5142)

1. M.P. Lachane J. Food Safety 4, 71, (1982)

Poe, B.S., and O'Neill, K.L., Caffeine modulates heat shock induced apoptosis in the human promyelocytic leukemia cell line HL-60. Cancer Lett. 121, 1-6, (1997)

Takagi, M., et al., DNA damage-associated cell cycle and cell death control is differentially modulated by caffeine in clones with p53 mutations. Leukemia 13, 70-77, (1999)

He, A.W., and Cory, J.G., p53-independent anisomycin induced G1 arrest and apoptosis in L1210 cell lines. Anticancer Res. 19, 421-428, (1999)

Hadfield, M.G., Caffeine and the olfactory bulb. Mol. Neurobiol. 15, 31-39, (1997)

Ferre, S., et al., Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia. Trends Neurosci. 20, 482-487, (1997)

Islam, M.S., et al., In situ activation of the type 2 ryanodine receptor in pancreatic beta cells requires cAMP-dependent phosphorylation. Proc. Natl. Acad. Sci. USA 95, 6145-6150, (1998)

Shafer, S.H., et al., Reduced DNA synthesis and cell viability in small cell lung carcinoma by treatment with cyclic AMP phosphodiesterase inhibitors. Biochem. Pharmacol. 56, 1229-1236, (1998)

Merck 13,1636

Beil. 26,461 / Beil. 26,IV,2338

Aldrich MSDS 1, 343:A / Corp MSDS 1 (1), 664:C / FT-IR 2 (3), 3668:B / FT-IR 1 (2), 710:B / IR-Spectra (3), 1287:D / IR-Spectra (2), 1120:B / NMR-Reference 2 (2), 586:A / RegBook 1 (2), 2467:A / Sax 6, 615 / Sigma FT-IR 1 (1), 581:A / Structure Index 1, 390:E:3

UN1544 6.1/PG 2

1

EV6475000