31381
Fluka

Dexamethasone

purum, ≥97.0% (HPLC)

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Synonym

9α-Fluoro-16α-methylprednisolone

Prednisolone F

(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione

Molecular Formula

C₂₂H₂₉FO₅

Molecular Weight

392.46

CAS Number

50-02-2

Beilstein Registry Number

2066651

MDL number

MFCD00064136

EG/EC Number

200-003-9

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Descriptions

Other Notes

Useful for the induction of liver metallothionein¹

Biochem/physiol Actions

Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

Properties

grade

purum

assay

≥97.0% (HPLC)

optical activity

[α]20/D +76±4°, c = 1% in dioxane

262-264 °C(lit.)

Gene Information

human ... NR3C1(2908)

References

Cited Reference

1. S.R. Quinones, R.S. Cousins Biochem. J. 219, 959, (1984) abstract

Reference

Llanos, S.L., and Roldan, A., Effect of dexamethasone on nitric oxide (NO) production by cultured astrocytes. Bio. Cell. 23, 29-35, (1999)

Wershil, B.K., et al., Dexamethasone and cyclosporin A suppress mast cell-leukocyte cytokine cascades by multiple mechanisms. Int. Arch. Allergy Immunol. 107, 323-324, (1995)

Riccardi, C., et al., Glucocorticoid hormone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes. Cell Death Differ. 6, 1182-1189, (1999)

Merck

Merck 13,2960

reference

Aldrich MSDS 1, 556:D / Corp MSDS 1 (1), 1039:B / FT-NMR 1 (3), 585:C / RegBook 1 (2), 2863:L / Sax 6, 2493 / Sigma FT-IR 1 (1), 1233:A / Structure Index 1, 458:A:8

Safety

Hazard Codes

Risk Statements

Safety Statements

36/37

WGK Germany

RTECS

TU3980000

Related Categories

... Chiral Building Blocks > Complex Molecules

FT-IR Raman

FT-NMR

MSDS

Certificate of Analysis

More Information