43070
Fluka

5,5-Diphenylhydantoin

purum, ≥96.0% (N)

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D4007, 5,5-Diphenylhydantoin

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Synonym

5,5-Diphenyl-2,4-imidazolidinedione

Phenytoin

Molecular Formula

C₁₅H₁₂N₂O₂

Molecular Weight

252.27

CAS Number

57-41-0

Beilstein Registry Number

384532

MDL number

MFCD00005264

PubChem Substance ID

24866937

EG/EC Number

200-328-6

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Descriptions

Biochem/physiol Actions

Reduces incidence of grand mal seizures; appears to stabilize excitable membranes perhaps through effects on Na⁺, K⁺, and Ca²⁺ channels.

Properties

grade

purum

assay

≥96.0% (N)

293-295 °C(lit.)

293-295 °C

solubility

acetone: 10 mg/mL, clear

Gene Information

human ... CNR1(1268), CNR2(1269), CYP2C9(1559)

rat ... Faah(29347), Scn1a(81574), Scnn1g(24768), Slc6a1(79212)

References

Reference

Nobile, M., and Lagostena, L., A discriminant block among K⁺ channel types by phenytoin in neuroblastoma cells. Br. J. Pharmacol. 124, 1698-1702, (1998)

Todorovic, S.M., Lingle, C.J., Pharmacological properties of T-type Ca²⁺ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents. J. Neurophysiol. 79, 240, (1998)

Rush, A.M., and Elliott, J.R., Phenytoin and carbamazepine: differential inhibition of sodium currents in small cells from adult rat dorsal root ganglia. Neurosci. Lett. 226, 95-98, (1997)

Morimoto, K., et al., BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy. Eur. J. Pharmacol. 339, 11-15, (1997)

Merck

Merck 13,7406

Beilstein

Beil. 24,IV,1748

reference

Aldrich MSDS 1, 826:D / Corp MSDS 1 (1), 1458:B / FT-IR 2 (2), 3060:C / FT-IR 1 (2), 398:C / FT-NMR 1 (2), 1446:C / IR-Spectra (3), 1096:F / IR-Spectra (2), 957:F / NMR-Reference 2 (2), 358:B / RegBook 1 (2), 2063:J / Sax 6, 1038 / Sigma FT-IR 1 (2), 524:C / Structure Index 1, 328:C:1

Safety

Hazard Codes

Risk Statements

45-61-22

Safety Statements

53-45

WGK Germany

RTECS

MU1050000

FT-IR Raman

FT-NMR

MSDS

Certificate of Analysis

More Information