43780
Fluka

Dimethyl 3,3′-dithiopropionimidate dihydrochloride

BioChemika, purum, ≥95.0% (AT)

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Replaced by

D2388, Dimethyl 3,3′-dithiopropionimidate dihydrochloride

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Synonym

Dimethyl 3,3′-dithio-bis(propionimidate) dihydrochloride

DTBP

Wang/Richards’ reagent

Molecular Formula

C₈H₁₆N₂O₂S₂ � 2HCl

Molecular Weight

309.28

CAS Number

38285-78-8

MDL number

MFCD00043245

PubChem Substance ID

24867398

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Descriptions

Analysis Note

product decomposes at 111-115°C, residual melts at 160-164°C

Application

A homobifunctional, cleavable cross-linking reagent. Typically, reacted with primary amines in the pH range 7.0-10.0 to form amidine bonds.

Caution

The reagant is readily hydrolyzed at neutral pH. Avoid use of reducing agents during coupling reactions.

Other Notes

Cleavable bifunctional reagent used for cross-linking of membrane proteins and hemoglobin¹; For the preparation of an activated solid support²; Cross-linking of a cytochrome oxidase complex³

Note that the amidine linkage preserves original primary amine positive charge. The disulfide linkage is cleavable by mild reduction. Incorporates an eight atom linker.

Properties

product line

BioChemika

grade

purum

assay

≥95.0% (AT)

storage temp.

2-8°C

References

Cited Reference

1. K. Wang, F.M. Richards J. Biol. Chem. 250, 6622, (1975) abstract

2. Y. Eshdat, A. Prujansky-Jakobo. FEBS Lett. 101, 43, (1984)

3. J. Jarausch, B. Kadenbach Eur. J. Biochem. 146, 211, (1985) abstract

Safety

Hazard Codes

Risk Statements

Safety Statements

WGK Germany

3-10-21

MSDS

Certificate of Analysis

More Information