44577
Fluka

Doxycycline hyclate

BioChemika, ≥98.0% (TLC)

This product number has been discontinued but a similar product may be available. Please select the recommended replacement product below (if a direct replacement is available) or use the links to "similar products" or "related product categories" to see other possible replacement products.

Recommended Products

Replaced by

D9891, Doxycycline hyclate

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Synonym

Doxycycline hydrochloride hemiethanolate hemihydrate

Molecular Formula

C₂₂H₂₄N₂O₈ � HCl � 1/2(H₂O) � 1/2(C₂H₆O)

Molecular Weight

512.94

CAS Number

24390-14-5

Beilstein Registry Number

5702728

MDL number

MFCD07357237

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Descriptions

Biochem/physiol Actions

Broad spectrum antibiotic; derivative of oxytetracycline. Broad spectrum inhibitor of matrix metalloproteinases in vivo.

Properties

product line

BioChemika

assay

≥98.0% (TLC)

total impurities

≤5% water

≤7% ethanol

solubility

H₂O: 50 mg/mL, clear, yellow-green

References

Reference

Burggraf, D. et al.,, Doxycycline inhibits MMPs via modulation of plasminogen activators in focal cerebral ischemia. Neurobiol. Dis. 25, 506-13, (2007)

Lamparter, S. et al.,, Doxycline and tissue repair in rats. J. Lab. Clin. Med. 139, 295-302, (2002)

Garcia, R.A. et al.,, Molecular interactions between matrilysin and the matrix mettalloproteinase inhibitor doxycycline investigated by deuterium exchange mass spectrometry. Mol. Pharmacol. 67, 1128-36, (2005)

Franco, C. et al.,, Doxycycline alters vascular smooth muscle cell adhesion, migration, and reorganization of fibrillar collagen matrices. Am. J. Pathol. 168, 1697-709, (2006)

Safety

Hazard Codes

Risk Statements

WGK Germany

MSDS

Certificate of Analysis

More Information