Guanosine 3′,5′-cyclic monophosphate sodium salt 

An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG).

BioChemika

≥99.0% (HPLC)

wet ice

−20°C

Vaandrager, A.B., and de Jonge, H.R., Signalling by cGMP-dependent protein kinases. Mol. Cell Biochem. 157, 23-30, (1996)

Lohmann, S.M., et al., Distinct and specific functions of cGMP-dependent protein kinases. Trends Biochem. Sci. 22, 307-312, (1997)

Wang, X., and Robinson, P.J., Cyclic GMP-dependent protein kinase and cellular signaling in the nervous system. J. Neurochem. 68, 443-456, (1997)

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Finn, J.T., et al., Cyclic nucleotide-gated ion channels: an extended family with diverse functions. Annu. Rev. Pharmacol. Toxicol. 58, 395-426, (1996)

Browning, D.D., et al., Activation of p38 mitogen-activated protein kinase by lipopolysaccharide in human neutrophils requires nitric oxide-dependent cGMP accumulation. J. Biol. Chem. 274, 537-542, (1999)

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