53460
Fluka

L-Homoarginine hydrochloride

BioChemika, ≥98.0% (TLC)

This product number has been discontinued but a similar product may be available. Please select the recommended replacement product below (if a direct replacement is available) or use the links to "similar products" or "related product categories" to see other possible replacement products.

Recommended Products

Replaced by

H1007, L-Homoarginine hydrochloride

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Synonym

(S)-2-Amino-6-guanidinohexanoic acid hydrochloride

Molecular Formula

H₂NC(=NH)NH(CH₂)₄CH(NH₂)CO₂H · HCl

Molecular Weight

224.69

CAS Number

1483-01-8

Beilstein Registry Number

4016621

MDL number

MFCD00012622

PubChem Substance ID

24878050

EG/EC Number

216-045-6

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Descriptions

Application

The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements.

Biochem/physiol Actions

Homoarginine is an inhibitor of tissue nonspecific alkaline phosphatase (TNALP). It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter.

Properties

product line

BioChemika

assay

≥98.0% (TLC)

213-215 °C(lit.)

solubility

H₂O: 50 mg/mL, clear to slightly hazy, faintly yellow

References

Reference

Choudhury, A.K., et al., Synthesis of proteins containing modified arginine residues. Biochemistry 46, 4066-4076, (2007)

Wu, F., et al., Characterization of L-arginine transporters in rat renal inner medullary collecting duct. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278, R1506-R1512, (2000)

Kozlenkov, A., et al., Residues determining the binding specificity of uncompetitive inhibitors to tissue-nonspecific alkaline phosphatase. J. Bone Miner Res. 19, 1862-1872, (2004)

Izdebski, J., et al., New potent hGH-RH analogues with increased resistance to enzymatic degradation. J. Pept. Sci. 8, 285-287, (2002)

Beilstein

Beil. 4,IV,2720

reference

FT-IR 2 (1), 1331:C / FT-IR 1 (1), 786:C / FT-NMR 1 (1), 1281:C / IR-Spectra (3), 466:C / IR-Spectra (2), 413:D / RegBook 1 (1), 919:E / Sigma FT-IR 1 (1), 183:D / Structure Index 1, 142:A:7

Safety

WGK Germany

FT-IR Condensed Phase

FT-IR Raman

FT-NMR

MSDS

Certificate of Analysis

More Information