Pyrroloquinoline quinone 

D7783, Pyrroloquinoline quinone

PQQ is present in nanomolar quantities in most foods and in most animal tissuse. It promotes growth, mitochondrial function, and development in vivo and stimulates cell proliferation and viability in culture. It is a potent antioxidant that scavenges superoxide and peroxinitrite. It is neuroprotectant against 6-hydroxydopamine-induced and hypoxia/ischemia-induced neurotoxicity. PQQ conjugates to α-synuclein in vitro, inhibiting the formation of amyloid fibrils.

Novel o-quinone coenzyme found in bacterial dehydrogenases and oxidases.

BioChemika

≥97.0% (HPLC)

≤15% water

2-8°C

Duine, J.A., The PQQ story. J. Biosci. Bioeng. 88, 231-236, (1999)

Duine, J.A., Quinoproteins, enzymes with pyrrolo-quinoline quinone as cofactor. Annu. Rev. Biochem. 58, 403-426, (1989)

Hara, H., et al., Pyrroloquinoline quinone is a potent neuroprotective nutrient against 6-hydroxydopamine-induced neurotoxicity. Neurochem. Res. 32, 489-495, (2007)

Kumazawa, T., et al., Activation of Ras signaling pathways by pyrroloquinoline quinone in NIH3T3 mouse fibroblasts. Int. J. Mol. Med. 19, 765-770, (2007)

Noji, N., et al., Simple and Sensitive Method for Pyrroloquinoline Quinone (PQQ) Analysis in Various Foods Using Liquid Chromatography/Electrospray-Ionization Tandem Mass Spectrometry. J. Agric. Food Chem. 55, 7258-7263, (2007)

Bauerly, K.A., et al., Pyrroloquinoline quinone nutritional status alters lysine metabolism and modulates mitochondrial DNA content in the mouse and rat. Biochim. Biophys. Acta 1760, 1741-1748, (2006)

Zhang, Y., et al., Neuroprotection by pyrroloquinoline quinone (PQQ) in reversible middle cerebral artery occlusion in the adult rat. Brain Res. 1094, 200-2006, (2006)

Stites, T., et al., Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice. J. Nutr. 136, 390-396, (2006)

Kobayashi, M., et al., Pyrroloquinoline quinone (PQQ) prevents fibril formation of α-synuclein. Biochem. Biophys. Res. Commun. 349, 1139-1144, (2006)

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