89193
Fluka

Cholecalciferol

Ph Eur

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Synonym

(+)-Vitamin D₃

7-Dehydrocholesterol activated

Activated 7-dehydrocholesterol

Calciol

Cholecalciferolum

Molecular Formula

C₂₇H₄₄O

Molecular Weight

384.64

CAS Number

67-97-0

Beilstein Registry Number

2339331

MDL number

MFCD00078131

PubChem Substance ID

24889192

EG/EC Number

200-673-2

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Descriptions

Biochem/physiol Actions

Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.

Properties

grade

Ph Eur

pharmacopeia

testing & handling conforms to Pharmacopeia

83-86 °C(lit.)

storage temp.

2-8°C

References

Reference

Leibowitz, S.B., and Kantoff, P.W., Differentiating agents and the treatment of prostate cancer: Vitamin D₃ and peroxisome proliferator-activated receptor γ ligands. Semin. Oncol. 30, 698-708, (2003)

Welsh, J., et al., Vitamin D₃ receptor as a target for breast cancer prevention. J. Nutr. 133, 2425S-2433S, (2003)

Holick, M.F., Evolution and function of vitamin D. Rec. Res. Canc. Res. 164, 3-28, (2003)

Palmer, H.G., et al., Genetic signatures of differentiation induced by 1α,25-dihydroxyvitamin D₃ in human colon cancer cells. Cancer Res. 63, 7799-7806, (2003)

Merck

Merck 13,10079

Beilstein

Beil. 6,IV,4149

reference

Aldrich MSDS 1, 1840:C / Corp MSDS 1 (2), 3609:A / FT-IR 2 (3), 4222:C / FT-IR 1 (2), 1049:D / FT-NMR 1 (3), 570:C / IR-Spectra (3), 1494:G / IR-Spectra (2), 1278:F / NMR-Reference 2 (2), 920:D / RegBook 1 (2), 2857:D / Sax 6, 787 / Sigma FT-IR 1 (1), 637:C / Structure Index 1, 457:B:7

Safety

Hazard Codes

T+

Risk Statements

24/25-26-48/25

Safety Statements

28-36/37

RIDADR

UN 2811 6.1/PG 2

WGK Germany

RTECS

VS2900000