242284
Sigma-Aldrich

Aniline

ACS reagent, ≥99.5%

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Molecular Formula

C₆H₅NH₂

Molecular Weight

93.13

CAS Number

62-53-3

Beilstein Registry Number

605631

MDL number

MFCD00007629

PubChem Substance ID

24854547

EG/EC Number

200-539-3

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Descriptions

Biochem/physiol Actions

The acute toxicity of aniline involves its activation in vivo to 4-hydroxyaniline and the formation of adducts with hemoglobin. In erythrocytes, this is associated with the release of iron and the accumulation of methemoglobin and the development of hemolytic anemia and inflammation of the spleen. Tumor formation is often observed in the spleen on prolonged administration.

Packaging

5, 100, 500 g in glass btl

Properties

grade

ACS reagent

vapor density

3.22 (185 °C, vs air)

vapor pressure

0.7 mmHg ( 25 °C)

assay

≥99.5%

autoignition temp.

1139 °F

expl. lim.

11 %

total impurities

Hydrocarbons, passes test

Nitrobenzene, passes test(lim. ~0.001%)

≤0.01% chlorobenzene

ign. residue

≤0.005%

color

≤250(APHA)

refractive index

n20/D 1.586(lit.)

184 °C(lit.)

−6 °C(lit.)

density

1.022 g/mL at 25 °C(lit.)

References

Reference

Zwirner-Baier, I., et al. , Biomonitoring of aromatic amines VI: determination of hemoglobin adducts after feeding aniline hydrochloride in the diet of rats for 4 weeks. Arch. Toxicol. 77, 672-67, (2003)

Ciccoli, L., et al., Hemolytic drugs aniline and dapsone induce iron release in erythrocytes and increase the free iron pool in spleen and liver. Toxicol. Lett. 110, 57-66, (1999)

Merck

Merck 13,661

Beilstein

Beil. 12,IV,223

Fieser

Fieser 6,21

reference

Aldrich MSDS 1, 125:D / Corp MSDS 1 (1), 270:A / FT-IR 2 (2), 2024:A / FT-IR 1 (1), 1189:A / FT-NMR 1 (2), 451:A / IR-Spectra (3), 714:A / IR-Spectra (2), 630:A / NMR-Reference 2 (1), 987:A / RegBook 1 (1), 1383:A / Sax 6, 280 / Sigma FT-IR 1 (2), 284:A / Structure Index 1, 214:A:1 / Vapor Phase 3, 1109:A

Safety

Hazard Codes

T,N

Risk Statements

23/24/25-40-41-43-48/23/24/25-50-68

Safety Statements

26-27-36/37/39-45-46-61-63

RIDADR

UN 1547 6.1/PG 2

WGK Germany

RTECS

BW6650000