D3506
Sigma-Aldrich

Sodium diethyldithiocarbamate trihydrate

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Synonym

Cupral

Diethyldithiocarbamic acid sodium salt

Molecular Formula

(C₂H₅)₂NCSSNa · 3H₂O

Molecular Weight

225.31

CAS Number

20624-25-3

Beilstein Registry Number

3920507

MDL number

MFCD00150617

PubChem Substance ID

24893758

EG/EC Number

205-710-6

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Descriptions

Biochem/physiol Actions

Inhibits induction of macrophage nitric oxide synthase.

Caution

May form insoluble oxidation products in storage. Sensitivity in colorimetric copper determination not usually affected.

Application

Spin trap used in conjunction with Fe²⁺ to detect NO in brain, kidney, liver, and other tissues. Simultaneous direct measurement of NO* and pO₂ has been reported. A copper chelator, it has been used to quantitate copper in biological materials by ESR and is an inhibitor of superoxide dismutase, ascorbate oxidase, and other enzymes.

Properties

vapor density

5.9 (vs air)

95-98.5 °C(lit.)

storage temp.

Room temp

References

Reference

Kishnani, N.S., et al., Diethyldithiocarbamate prolongs survival of mice in a lipopolysaccharide-induced endotoxic shock model: evidence for multiple mechanisms. Shock 11, 264-268, (1999) abstract

Suzuki, Y., et al., In vivo nitric oxide detection in the septic rat brain by electron paramagnetic resonance. Free Radic. Res. 28, 293-299, (1998) abstract

Vanin, A.F., Iron diethyldithiocarbamate as spin trap for nitric oxide detection. Meth. Enzymol. 301, 269, (1999)

James, P.E., Simultaneous measurement of NO(*) and PO₂ from tissue by in vivo EPR. Nitric Oxide 3, 292, (1999)

Wallis, G., In vivo spin trapping of nitric oxide generated in the small intestine, liver, and kidney during the development of endotoxemia: a time-course study. Shock 6, 274, (1996)

Minakata, K., Quantification of copper in biological materials by use of electron spin resonance. Clin. Chem. 47, 1863, (2001)

James, P.E., et al., Direct detection of tissue nitric oxide in septic mice. Adv. Exp. Med. Biol. 454, 181-187, (1998) abstract

reference

RegBook 1 (1), 977:I

Safety

Hazard Codes

Risk Statements

22-38-41

Safety Statements

26-39

WGK Germany

RTECS