O8001
Sigma-Aldrich

Octyl β-D-glucopyranoside

≥98% (GC)

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Synonym

n-Octyl glucoside

OGP

Molecular Formula

C₁₄H₂₈O₆

Molecular Weight

292.37

CAS Number

29836-26-8

Beilstein Registry Number

84118

MDL number

MFCD00063288

PubChem Substance ID

24898051

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Descriptions

Application

Non-ionic, dialyzable detergent for the solubilization and isolation of membrane proteins. Has been shown to increase the resolution of proteins in 2D gels.

Enhanced Quality Profile

The Enhanced Quality Profile (EQP) is an SAFC program characterizing a product’s quality traits in a 5-level system to meet the requirements of our manufacturing customers. This product is in the PREMIUM level.

Properties

assay

≥98% (GC)

mol wt

micellar avg mol wt 25,000

aggregation number

CMC

20-25 mM(20-25°C)

transition temp

cloud point >100 °C

storage temp.

−20°C

References

Reference

G.W. Stubbs, Nonionic detergent with no absorbance at 228 μm, best suited for the solubilisation and isolation of membrane proteins. Biochim. Biophys. Acta 426, 46, (1976)

Lopez, M.F., Proteome analysis. I. Gene products are where the biological action is. J. Chromatogr. 722, 191-202, (1999)

Aveldano, M.I., et al., Solubilization of myelin membranes by detergents. J. Neurochem. 57, 250-257, (1991)

Dainese Hatt, P.,, Concentration of, and SDS removal from proteins isolated from multiple two-dimensional electrophoresis gels. Eur. J. Biochem. 246, 336-343, (1997)

Holloway, P.J. and Arundel, P.H., High-resolution two-dimensional electrophoresis of plant proteins. Anal. Biochem. 172, 8-15, (1988)

J.S. Lazo, D.E. Quinn Anal. Biochem. 102, 68, (1980)

B. Lorber, L.J. DeLucas, Changes in physico-chemical properties during membrane protein crystallization using a salt as precipitant. J. Cryst. Growth 110, 103, (1991)

G. Halldén J. Immunol. Methods 124, 103, (1989)

W.J. Schneider J. Biol. Chem. 255, 11442, (1980)

S. Han, M.L. Tanzer J. Biol. Chem. 254, 10438, (1979)

Biochemistry 17, 215, (1978)

Gould, R.J., et al., Effects of octyl beta-glucoside on insulin binding to solubilized membrane receptors. Biochemistry 20, 6776, (1981)

Beilstein

Beil. 17,V,7,38

Safety

3-10